四磨汤口服液联合枳术宽中胶囊治疗消化系统恶性肿瘤术后胃肠功能紊乱的临床疗效观察

Clinical observation on the treatment of gastrointestinal dysfunction following digestive system malignant tumor Treated by Simoyu Oral Liquid and Qizhuan Kuanzhong Capsule

目的 观察四磨汤口服液联合枳术宽中胶囊治疗消化系统恶性肿瘤术后胃肠功能紊乱的临床疗效。方法 纳入2016年6月至2018年4月在两院行消化系统恶性肿瘤切除术后出现胃肠功能紊乱113例患者作为研究对象,按随机数字表法分为联合组(40例)、单药组(38例)与对照组(35例),对照组术后给予常规治疗,单药组在对照组基础上给予枳术宽中胶囊治疗,联合组给予四磨汤口服液联合枳术宽中胶囊治疗,观察三组临床治疗效果。结果 联合组治疗后腹胀、恶心呕吐、排便困难、喛气程度显著轻于单药组、对照组,三组比较,具有显著性差异(P<0.05)。治疗后,联合组与单药组血清NO、CCK水平较治疗前明显降低,AchE、SP水平较治疗前明显提高,联合组血清NO、CCK水平显著低于单药组、对照组,AchE、SP水平显著高于单药组、对照组(P<0.05),对照组治疗前后血清NO、CCK、AchE、SP水平比较无显著性差异(P>0.05)。治疗后联合组术后禁食时间、排气排便时间、肠鸣音恢复时间及腹胀消失时间均明显短于单药组、对照组(P<0.05);联合组临床总有效率(95.00%)显著高于单药组(76.32%)和对照组(6.67%),差异均有统计学意义(P<0.05)。结论 四磨汤口服液联合枳术宽中胶囊治疗消化系统恶性肿瘤术后胃肠功能紊乱可有效减轻患者临床症状,促进患者胃肠功能恢复,且具有减轻肠道运动抑制、兴奋胃肠道平滑肌作用,临床疗效显著,在消化系统恶性肿瘤术后胃肠功能紊乱的临床治疗中具有重要价值。

Objective To observe the clinical efficacy of Si Mo Tang Oral Liquid combined with Zhizhu Kuanzhong Capsule in the treatment of gastrointestinal dysfunction after digestive system malignancy. Methods A total of 113 patients with gastrointestinal dysfunction after digestive system malignant tumor resection in our hospital from June 2016 to April 2018 were enrolled. The patients were divided into two groups according to the random number table (40 cases). The drug group (38 cases) and the control group (35 cases),the control group received routine treatment after surgery,the single drug group was given Qizhuanzhongzhong capsule on the basis of the control group,and the combined group was given Sizhutang oral solution combined with phlegm and blood stasis. In the treatment of capsules,the clinical effects of the three groups were observed. Results In the combined group,abdominal distension,nausea and vomiting,difficulty in defecation,and degree of hernia were significantly lower than those in the single-agent group and the control group. There were significant differences between the three groups (P < 0. 05). Serum NO and CCK in the combined group and the single-agent group. The levels of AchE and SP were significantly lower than those before treatment. The levels of serum NO and CCK in the combined group were significantly lower than those in the single drug group and the control group. The levels of AchE and SP were significantly higher than those in the single drug group and the control group (P < 0. 05),there was no significant difference in serum NO,CCK,AchE and SP levels before and after treatment in the control group (P > 0. 05). After treatment,the fasting time,exhaust defecation time,recovery time of bowel sounds and abdominal distension disappeared in the combined group. The time was significantly shorter than that of the single drug group and the control group (P < 0. 05). The total effective rate (95. 00%) of the combined group was significantly higher than that of the single drug group (76. 32%) and the control group (6. 67%)(P < 0. 05).Conclusion Si Mo Tang Oral Liquid combined with Qizhu Kuanzhong Capsule can effectively relieve the clinical symptoms of patients with digestive system malignant tumor after gastrointestinal disorders,promote the recovery of gastrointestinal function,and reduce intestinal motility inhibition and excitement of gastrointestinal smooth muscle. The role,clinical efficacy is significant,in the clinical treatment of gastrointestinal dysfunction after digestive system malignant tumor has important value.