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新生儿与孕母维生素D水平的相关性分析 被引量:3

Correlation analysis of vitamin D between newborns and their mothers
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摘要 目的分析新生儿与孕母维生素D水平的相关性。方法选取2017年11月—2019年1月哈尔滨医科大学附属第一医院待产的孕妇及其娩出新生儿各80例。分别测定孕母产前静脉血及新生儿出生后72h内静脉血25羟维生素D[25(OH)D]水平。结果新生儿25(OH)D平均为(13.96±6.09)ng/ml,其中47例(58.75%)存在维生素D缺乏,22例(27.50%)存在维生素D不足,11例(13.75%)维生素D水平适宜;孕母产前25(OH)D平均为(14.54±7.17)ng/ml。新生儿25(OH)D水平在胎龄、分娩方式、性别方面比较,差异无统计学意义(P>0.05),但在出生体重、季节方面比较,差异有统计学意义(P<0.05),夏秋季节高于冬春季节。新生儿25(OH)D水平和孕母孕晚期25(OH)D水平呈正相关(rs=0.824,P=0.000)。以孕母25(OH)D水平4.75ng/ml为界值,对应的敏感性为97.9%(95%CI:0.607,0.838),特异性为71.4%(95%CI:0.655,0.981)。结论黑龙江地区新生儿维生素D水平偏低,与孕母维生素D水平成正相关;与出生体重、季节存在相关性,测定孕母维生素D水平,可帮助判断新生儿维生素D营养状态。 Objective To analyze the correlation between neonatal and maternal vitamin D levels. Methods To measure vitamin D levels of 80 newborns within 72h after birth and their mothers within a week before delivery, from November 2017 to January 2019 in Heilongjiang province. Results Neonatal average vitamin D level is (13.96±6.09) ng/ml, the rate of vitamin D insufficiency is 27.50%, and the rate of vitamin D deficiency is 58.75%;maternal average vitamin D level is (14.54±7.17) ng/ml;neonatal vitamin D level is related with birth weight and season (P < 0.05), rather than gestational age, delivery mode and gender (P > 0.05);Neonatal 25 (OH) D level is positively correlated with maternal vitamin D level (r s =0.824, P = 0.000). The sensitivity and specificity to predict neonatal vitamin D deficiency when maternal 25 (OH) D level lower than 4.75ng/ml were 97.9%(95% CI: 0.607, 0.838) and 71.4%(95% CI: 0.655, 0.981). Conclusions Neonatal vitamin D level is low in Heilongjiang province, it is correlated with maternal vitamin D level, as well as birth weight and season. Maternal vitamin D levels can help predict the levels of newborns.
作者 于嘉 王竹颖 Jia Yu;Zhu-ying Wang(Department of Neonatology, the First Affiliated Hospital of Harbin Medical University,Harbin, Heilongjiang 150001, China)
出处 《中国现代医学杂志》 CAS 2019年第16期95-98,共4页 China Journal of Modern Medicine
关键词 婴儿 新生 维生素 替身母亲 infant, newborn vitamins surrogate mothers
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