前列地尔联合常规治疗对2型糖尿病周围神经病变患者的临床疗效分析

Efficacy of Alprostadil Combined with Conventional Therapy in Patients with Type 2 Diabetic Peripheral Neuropathy

目的探讨前列地尔联合常规治疗对2型糖尿病周围神经病变患者的临床效果。方法选择2016年7月—2018年10月收治的86例2型糖尿病周围神经病变患者,随机分为观察组和对照组,各43例,对照组给予甲钴胺与常规治疗,观察组给予前列地尔联合常规治疗。结果治疗后,观察组治疗有效率88.37%明显高于对照组的67.44%(P<0.05);观察组运动及感觉神经传导速度、抗氧化能力均高于对照组(P<0.05);多伦多临床神经病变评分、疼痛评分、半胱氨酸水平均低于对照组(P<0.05)。结论前列地尔联合常规治疗可明显改善2型糖尿病周围神经病变患者的临床症状及神经传导速度,减缓神经病变进展。

Objective To investigate the clinical effect of alprostadil combined with conventional therapy on type 2 diabetic peripheral neuropathy. Methods A total of 86 patients with type 2 diabetic peripheral neuropathy from July 2016 to October 2018 were randomly divided into observation group(43 cases) and control group(43 cases). The control group was given mecobalamin and routine treatment, while the observation group was given alprostadil combined with routine treatment. Results After treatment, the effective rate of the observation group was 88.37%, which was significantly higher than that of the control group (67.44%)(P<0.05). The motor and sensory nerve conduction velocity, T-AOC of the observation group were higher than those of the control group(P<0.05). The Toronto clinical neuropathy score, pain score and cysteine level were lower than those of the control group(P<0.05). Conclusion Alprostadil combined with routine treatment can significantly improve the clinical symptoms and nerve conduction velocity of patients with type 2 diabetic peripheral neuropathy, and slow down the progress of neuropathy.