舒血宁联合复方丹参片对急性脑梗塞患者血清超敏C反应蛋白、脂蛋白的影响及其临床疗效

Effect of the serum high sensitive C reactive protein,lipoprotein and clinical efficacy by Shuxuening combined with Compound Salvia Tablet in the treatment of patients with acute cerebral infarction

目的探讨舒血宁联合复方丹参片对急性脑梗塞患者(ACI)血清超敏C反应蛋白、脂蛋白的影响及其临床疗效。方法选取青海省人民医院2014年4月~2015年9月收治的80例ACI患者,随机分为对照组和观察组,每组40例。对照组给予舒血宁注射液静脉滴注,研究组在此基础上,再予以复方丹参片口服。检测两组相关生化指标及血液流变学的变化,NIHSS及BI评分评估治疗前后神经功能及日常生活能力,NIHSS评分比较其临床疗效。结果与治疗前比较,两组hs-CRP、LP、PAF及LP-PLA2水平均明显降低(P<0.05),血液流变学指标亦明显降低(均P<0.05),NIHSS评分显著降低(P<0.05),BI评分显著升高(P<0.05);与对照组比较,观察组hs-CRP、LP、PAF及LP-PLA2水平均较低(均P<0.05),血液流变学指标及NIHSS评分均较低(均P<0.05),但BI评分较高(P<0.05),治疗有效率较高(P<0.05)。结论舒血宁联合复方丹参片能有效治疗急性脑梗塞,改善血液流变学,促进神经功能的恢复及预后,且能降低hs-CRP及LP水平。

ObjectiveTo investigate the effect of the serum high sensitive C reactive protein, lipoprotein and clinical efficacy by Shuxuening combined with Compound Salvia Tablet in the treatment of patients with acute cerebral infarction. Methods80 patients with acute cerebral infarction were selected and randomly divided into the control group and the experiment group with 40 cases in each group. The control group was treated by Shuxuening Injection for intravenous injection and the experiment group was treated on the base of the control group with Compound Salvia Tablet oral. The changes of biochemical indexes and blood rheology were detected before and after the treatment. The nerve function and the ability of daily life were evaluated. ResultsThe hs-CRP, LP, PAF, LP-PLA2, blood rheology index and NIHSS score after treatment were lower than that before treatment ( P <0.05). The BI score after treatment was higher than that before treatment ( P <0.01).Compared with the control group, The hs-CRP, LP, PAF, LP-PLA2, blood rheology index and NIHSS after treatment of experiment group were lower that after treatment of control group ( P <0.05). The BI score after treatment of experiment group was higher that after treatment of control group ( P <0.05). ConclusionShuxuening combined with Compound Danshen tablet is effective in the treatment of acute cerebral infarction, improve blood rheology, promote the nerve function recovery and prognosis and decrease of hs CRP and LP levels.