小儿哮喘应用不同雾化吸入方式治疗的疗效探讨

Therapeutic Effect of Different Inhalation Methods for Children with Asthma

目的研究探讨小儿哮喘应用不同雾化吸入方式治疗的临床疗效。方法方便选择该院儿科收治的100例哮喘患儿(2017年1月—2018年9月)进行前瞻性研究,随机分为2组各50例,两组均给予布地奈德、异丙托溴铵联合治疗,对照组采用空气压缩泵雾化吸入给药,观察组采用氧驱动雾化吸入给药,比较两组的临床疗效、症状及体征改善情况、肺通气功能指标、血气分析指标、不良反应发生率。结果①观察组的总有效率(96%)较对照组高(χ^2=5.005,P<0.05),其咳嗽缓解时间(2.29±0.54)d、喘息缓解时间(1.90±0.65)d、哮鸣音消失时间(1.41±0.66)d均较对照组缩短(t=6.577、5.609、5.504,P<0.05)。②治疗后,观察组的FEV1(2.09±0.69)L、FEV1/FVC(58.94±15.67)%、PaO2(85.92±21.97)mmHg均高于对照组(t=5.215、5.838、5.677,P<0.05),其PaCO2(35.08±6.79)mmHg低于对照组(t=9.539,P<0.05)。③观察组与对照组不良反应发生率分别为2%、4%,差异无统计学意义(χ^2=0.344,P>0.05)。结论氧驱动雾化吸入给药较空气压缩泵雾化吸入给药可更加有效地改善哮喘患儿病情,促进其肺通气功能、血气状况恢复,有利于提高临床疗效,且安全性良好。

Objective To study the clinical efficacy of different aerosol inhalation methods in children with asthma.Methods A prospective study was performed in 100 children with asthma admitted to our hospital from January 2017 to September 2018.They were convenient randomly divided into two groups of 50 patients.Both groups were given budesonide and ipratropium bromide.Ammonium combined therapy,the control group was administered by air compression pump,and the observation group was treated with oxygen-driven aerosol inhalation.The clinical efficacy,symptoms and signs improvement,lung ventilation function index,blood gas analysis index,and rate of reaction were compared between the two groups.Results 1.The total effective rate of the observation group(96%)was higher than that of the control group(χ^2=5.005,P<0.05),the cough remission time(2.29±0.54)d,wheezing remission time(1.90±0.65)d,wheezing time of disappearance of sound(1.41±0.66)%was shorter than that of the control group(t=6.577,5.609,5.504,P<0.05).2.After treatment,the FEV1(2.09±0.69)L,FEV1/FVC(58.94±15.67)%,and PaO2(85.92±21.97)in the observation group were higher than the control group(t=5.215,5.838,5.677,P<0.05).PaCO2(35.08±6.79)mmHg was lower than the control group(t=9.539,P<0.05).3.The incidence of adverse reactions in the observation group and the control group were 2%and 4%,respectively,and the difference was not statistically significant(χ^2=0.344,P>0.05).Conclusion Oxygen-driven nebulized inhalation administration can effectively improve the condition of children with asthma and promote the recovery of lung ventilation and blood gas status,which is beneficial to improve clinical efficacy and safety.