自噬在阿尔兹海默病发病机制中的作用

Advances in research on autophagy and Alzheimer’s disease

阿尔茨海默病(Alzheimer’sdisease,AD)是一种起病隐匿、病程呈进行性发展的神经退行性疾病,其发病机制目前尚未明确。自噬是清除哺乳动物细胞中异常蛋白质聚集体的重要降解途径,其可通过清除变性或错误折叠的蛋白质、衰老或损伤的细胞器,从而维持细胞正常的稳态效应。本文对细胞自噬在AD中的作用进行了阐述,以期为发现AD的发病机制及治疗靶点提供新思路。

Alzheimer's disease (AD) is a neurodegenerative disease with insidious onset and progressive progression.The pathogenesis of this disease is not yet clear.Autophagy is an important pathway for the removal of abnormal protein aggregates in mammalian cells by maintaining degenerative or misfolded proteins,aging or damaged organelles,thereby maintaining the normal homeostatic effects of cells.This article describes the role of autophagy in Alzheimer's disease,in order to provide new ideas for the pathogenesis and therapeutic targets of AD.