探讨丁苯酞注射液联合阿替普酶静脉溶栓对急性脑梗死患者神经功能及生活质量的影响

Investigation of Influence of Butylphthalide Injection Combined with Intravenous Thrombolysis with Ateplase for Neurological Function and Quality of Life in Patients with Acute Cerebral Infarction

目的:急性脑梗死(Acute cerebral infarct,ACI)应用丁苯酞注射液联合阿替普酶静脉溶栓治疗,研究其对患者神经功能和生活质量的影响。方法:择取2017年1月-2019年1月本院ACI患者106例,随机抽取53例作为对照组,采用阿替普酶静脉溶栓治疗,其余53例作为观察组,在对照组基础上加用丁苯酞注射液。对比两组治疗前后生活质量和神经功能。结果:治疗前,两组精神健康(MH)、情感职能(RE)、社会功能(SF)、生理功能(PF)四项评分比较,差异均无统计学意义(P>0.05);治疗后两组各项生活质量评分均高于治疗前(P<0.05),观察组MH、RE、SF、PF评分均明显高于对照组(P<0.05)。治疗前,两组美国国立卫生研究院卒中量表(NIHSS)评分比较,差异无统计学意义(P>0.05);治疗后两组NIHSS评分均低于治疗前(P<0.05)。观察组明显低于对照组(P<0.05)。结论:针对ACI应用丁苯酞注射液联合阿替普酶静脉溶栓治疗方案,可促进患者神经功能恢复,提高生活质量,整体疗效显著,具有较高的临床价值。

Objective:To study the influence of Butylphthalide Injection combined with intravenous thrombolysis with Ateplase for neurological function and quality of life in patients with acute cerebral Infarction(ACI).Method:A total of 106 cases of patients with ACI treated in our hospital from January 2017 to January2019 were selected,53 cases were randomly selected as control group and were treated with Intravenous thrombolysis with Ateplase,while other 53 cases were selected as observation group,and were treated with Butylphthalide injection on the basis of control group.The quality of life and neurological function of two groups before and after treatment were compared.Result:Before treatment,there were no significant differences in the scores of mental health(MH),emotional function(RE),social function(SF)and physiological function(PF)between the two groups(P<0.05).Each life quality scores of the two groups were higher after treatment than those of before treatment(P<0.05).After treatment,the scores of MH,RE,SF and PF in the observation group were significantly higher than those in the control group(P<0.05).Before treatment,there was no statistically significant difference in national institutes of health stroke scale(NIHSS)scores between the two groups(P>0.05).The NIHSS scores of two groups after treatment were lower than those of before treatment(P<0.05).After treatment,the NIHSS score in the observation group(3.35±0.37)scores was significantly lower than(5.36±0.73)scores in the control group(P<0.05).Conclusion:The clinical application of Butylphthalide Injection combined with intravenous thrombolysis with Ateplase for ACI can promote the recovery of neurological function and improve the quality of life of patients,and the overall effect are significant,thus it has a high clinical value.