布地奈德联合螺内酯对支气管肺发育不良早产儿血液中IL-1β、TNF-α变化的影响

Effect of Budesonide Combined with Spironolactone on Changes of IL-1β and TNF-α in Blood of Premature Infants with Bronchopulmonary Dysplasia

目的:探讨布地奈德联合螺内酯对支气管肺发育不良(BPD)早产儿血液中IL-1β、TNF-α变化的影响。方法:选取2012年11月-2017年11月在本院出生的早产儿92例,患儿均有BPD症状。按照随机数字表法将其分为对照组与研究组,各46例。对照组给予螺内酯治疗,研究组应用布地奈德联合螺内酯治疗。对比两组炎性因子水平(IL-1β、TNF-α、IL-8)、临床指标、体重、血气分析指标、并发症。结果:治疗后,研究组IL-1β、TNF-α、IL-8水平均低于对照组(P<0.05);治疗后,研究组心率、呼吸频率、经皮血氧饱和度、体重、血气分析指标均优于对照组(P<0.05);研究组并发症发生率为8.7%,低于对照组的32.6%,差异有统计学意义(χ^2=8.026,P<0.05)。结论:应用布地奈德联合螺内酯治疗早产儿BPD,可以显著改善患儿血液中IL-1β、TNF-α、IL-8等炎性因子水平,调节血气指标,安全有效,值得推广。

Objective:To investigate the effect of Budesonide combined with Spironolactone on the changes of IL-1βand TNF-αin blood of premature infants with bronchopulmonary dysplasia(BPD).Method:92 cases of premature infants born in our hospital from November 2012 to November 2017 were selected,all of them had BPD symptoms.According to the random number table method,they were divided into control group and study group,46 cases in each group.The control group was treated with Spironolactone,while study group was treated with Budesonide combined with Spironolactone.The levels of inflammatory factors(IL-1β,TNF-α,IL-8),clinical indicators,body weight,blood gas analysis indicators and complications were compared between two groups.Result:After treatment,the levels of IL-1β,TNF-α,IL-8 in study group were lower than those of control group(P<0.05).After treatment,the indexes of heart rate,respiratory rate,percutaneous oxygen saturation,body weight and blood gas analysis in study group were better than those of control group(P<0.05).The incidence of complications was 8.7%in study group,which was lower than 32.6%of control group(χ^2=8.026,P<0.05).Conclusion:The application of Budesonide combined with Spironolactone in treatment of BPD in premature infants can significantly improve the levels of IL-1β,TNF-α,IL-8 and other inflammatory factors in the blood of the infants,regulate blood gas indicators,which is safe and effective,and is worthy of promotion.