抑制胶质瘤细胞增殖与浸润相关的微小RNA研究进展

Advances in research on miRNAs inhibiting proliferation and infiltration of glioma cells

胶质瘤是来源于神经上皮组织的恶性肿瘤,在中枢神经系统中最为常见,恶性率高,肿瘤边界不清,常规的手术治疗很难彻底清除,临床上对于胶质细胞瘤的根治尚无确切的治疗方法。近年来的研究认为胶质瘤在本质上属多基因病变,其发生、发展受多种基因调节。而微小RNA(miRNAs)在肿瘤的增殖、分化、凋亡、转移、侵袭等作用中起着重要的作用。在基因调控水平上研究相关因子之间的关系、寻找新的分子基因靶点成为热门,本文综述了对胶质瘤细胞增殖及浸润起到抑制作用的miRNAs,希望对胶质瘤细胞的基因靶向治疗提供依据。

Glioma is a malignant tumor of neuroepithelial tissue. It is most common in the central nervous system.It has the characteristic of higher malignant rate, not clear tumour boundary and difficult to completely remove the conventional surgical treatment. There is no exact treatment for the treatment of glioma in clinical practice. The research suggests that glioma is a polygenic disease in nature, and its occurrence and development are regulated by various genes. However, micro RNA(miRNAs) plays an important role in tumor proliferation, differentiation, apoptosis, metastasis, invasion and other functions. At the level of gene regulation, it has become a hot topic to study the relationship between related factors and search for new molecular gene targets.This paper reviewed the inhibition of miRNAs on the proliferation and invasion of glioma cells, hoping to provide evidence for gene targeted therapy of glioma cells.