“益五合方”联合雌孕激素人工周期治疗肾虚血瘀型中-重度宫腔粘连术后临床研究

A clinical study on treating moderate to severe intrauterine adhesions of the Shenxu Xueyu symptom with the Yiwuhe prescription plus artificial cycle with estrogen and progesterone

目的:观察"益五合方"联合雌孕激素人工周期治疗肾虚血瘀型中-重度宫腔粘连宫腔镜下分离术后的临床疗效。方法:回顾性分析46例肾虚血瘀型中-重度宫腔粘连患者,在宫腔镜下分离粘连后,随机分为观察组与对照组,两组均行雌孕激素人工周期治疗,观察组同时服用中药"益五合方"。两组患者均治疗3个周期后观察并比较术后月经恢复情况,子宫内膜厚度、子宫容积及子宫腔形态,术后妊娠情况。结果:术后观察组宫腔粘连评分(7.88±4.96)分,低于对照组的(12.05±7.62)分,P<0.05。术后观察组平均月经量(37.67±21.71)m L,高于对照组的(24.05±17.48)m L,P<0.05。术后观察组黄体期子宫内膜厚度(7.00±1.10) mm、宫腔容积(4.76±0.78)m L,高于对照组子宫内膜厚度(6.15±1.69)mm、宫腔容积(4.30±0.76)m L P<0.05。观察组妊娠率为58.33%,高于对照组的27.27%,P<0.05。结论:"益五合方"联合雌孕激素人工周期治疗肾虚血瘀型中-重度宫腔粘连宫腔镜下分离术后的患者,具有良好的疗果,值得临床推广。

Objective: To observe clinic effects of the Yiwuhe prescription(益五合方) plus artificial cycle with estrogen and progesterone on moderate to severe intrauterine adhesions of the Shenxu Xueyu symptom(肾虚血瘀型). Methods: 46 women were divided into the observation group and the control group. Both groups were treated by artificial cycle with estrogen and progesterone. The observation group took the Yiwuhe prescription more. Results: IUA rating was 7.88±4.96 in the observation group, lower than 12.05±7.62 in the control group(P<0.05). The average amount of menstruation was(36.67±21.71) m L in the observation group, higher than(24.05±17.48) m L in the control group(P<0.05). Endometrial thickness was(7.00±1.10) mm in the observation group, thicker than(6.15±1.69) mm in the control group. Luteal phase and uterine cavity volume in the observation group was(4.76±0.78) m L, and(4.30±0.76) m L in the control group. Efficacy was 58.33% in the observation group, and 27.27% in the control group. Conclusion: The Yiwuhe prescription plus artificial cycle with estrogen and progesterone was effective, and is worthy of promotion.