麝香保心丸对冠状动脉粥样硬化性心脏病(冠心病)血管内皮功能的影响

Effect of Shexiang Baoxin Pill on Vascular Endothelial Function in Patients with Coronary Atherosclerotic Heart Disease(CHD)

目的:分析麝香保心丸对冠状动脉粥样硬化性心脏病(简称冠心病)血管内皮功能的影响。方法:选取2017年1月-2018年1月本院收治84例冠心病患者,分为两组,对照组42例采用常规用药治疗,试验组42例在常规用药基础上使用麝香保心丸,对两组血管内皮功能变化比较。结果:试验组治疗后肱动脉介导内皮舒张功能指标优于对照组(P <0.05);试验组治疗后3个月、6个月一氧化氮合酶指标分别(42.66±11.89)(U·mL^-1)、(48.39±16.27)(U·mL^-1),超氧化物歧化酶指标分别为(91.38±18.77)(U·mL^-1)、(93.07±15.36)(U·mL^-1)试验组一氧化氮合酶及超氧化物歧化酶优于对照组(P <0.05)。结论:麝香保心丸治疗冠状动脉粥样硬化性心脏病患者临床效果显著,提高冠心病患者治疗疗效,值得临床推广和使用。

Objective: To analyze the effect of Shexiang Baoxin Pill(麝香保心丸) on vascular endothelial function in patients with coronary atherosclerotic heart disease(CHD). Methods: From January 2017 to January 18, 2017, 84 patients with severe coronary heart disease were enrolled in this hospital. They were divided into two groups. 42 patients in the control group were treated with conventional medication, and 42 patients in the experimental group were treated with musk-protection pills on the basis of conventional medication.Comparison of changes in vascular endothelial function between the two groups. Results: The brachial artery-mediated endothelial dilation function index was better in the experimental group than in the control group(P < 0.05). The experimental group had the nitric oxide synthase index(42.66±11.89) at 3 and 6 months after treatment(U·mL^-1),(48.39±16.27)(U·mL^-1), the indexes of superoxide dismutase in the experimental group were(91.38±18.77)(U·mL^-1) at 3 months and 6 months after treatment,respectively.(93.07±15.36)(U·mL^-1),the experimental group nitric oxide synthase and superoxide dismutase were superior to the control group(P < 0.05). Conclusion: The clinical effect of Shexiang Baoxin Pill(麝香保心丸) in the treatment of patients with coronary atherosclerotic heart disease is significant,and the therapeutic effect of patients with coronary heart disease is improved. It is worthy of clinical promotion and use.