血浆同型半胱氨酸浓度与高血压病脑出血预后分析及其治疗

Prognosis analysis and treatment of plasma homocysteine concentration and hypertensive intracerebral hemorrhage

目的:观察血浆同型半胱氨酸浓度与高血压病脑出血的预后关系。方法:选取2014年6月-2017年6月在我院诊治的68例高血压病脑出血患者临床资料,设观察组,另取同期于我院体检的68例健康者,设对照组,均行血清检测,比较两组血清Hcy水平。结果:观察组血清Hcy水平(25.63±4.98)μmol/L比对照组高(P <0.05);与轻度组比,中度组、重度组的血清Hcy水平(19.31±3.14)μmol/L、(22.38±3.19)μmol/L均较高(P <0.05),重度组血清Hcy水平高于中度组(P <0.05);与康复组比,未愈组、死亡组的血清Hcy水平(20.32±3.26)μmol/L、(25.14±4.23)μmol/L均较高(P <0.05),死亡组血清Hcy水平比未愈组高(P <0.05)。结论:血浆Hcy水平浓度能有效监测高血压病脑出血的病情程度及预后,随Hcy水平升高,高血压病脑出血病情越重,且预后不佳。

Objective: To observe the relationship between plasma homocysteine concentration and prognosis of hypertensive cerebral hemorrhage. Methods: The clinical data of 68 patients with hypertensive intracerebral hemorrhage diagnosed in our hospital from June 2014 to June 2017 were selected as the observation group, and 68 healthy subjects in the same period admitted to and treated in the hospital were selected as the control group. Serum tests were performed to compare serum Hcy levels in both groups. Results: The serum Hcy level(25.63±4.98)μmol/L in the observation group was higher than that in the control group(P < 0.05). Compared with the mild group, the serum Hcy level in the moderate group(19.31±3.14)μmol/L and the severe group(22.38±3.19)μmol/L were higher(P < 0.05),serum Hcy level was higher in the severe group than that in the moderate group(P < 0.05). Compared with the rehabilitation group, the serum Hcy level in the unhealed group(20.32±3.26)μmol/L and the death group(25.14±4.23)μmol/L were higher(P < 0.05), and the serum Hcy level in the death group was higher than that in the unhealed group(P < 0.05). Conclusion: Plasma Hcy level could effectively monitor the severity and prognosis of hypertensive cerebral hemorrhage. With the increasing of Hcy level, the hypertensive cerebral hemorrhage was more serious and the prognosis was not good.