血清降钙素原在老年心衰合并肺炎患者抗感染治疗中的价值

The Value of Serum Procalcitonin in Anti-Infective Therapy for Elderly Patients with Heart Failure and Pneumonia

目的老年心衰合并肺炎患者在抗感染治疗中通过血清降钙素原对抗生素的水平进行控制,对患者的治疗指标进行分析,评价血清降钙素原的治疗价值.方法该次研究,从该院2016年1月—2018年3月期间,从而随即选取80例老年心衰合并肺炎患者,对其进行治疗研究,根据是否采取血清降钙素原展开对症治疗进行分组,通过血清降钙素原水平对患者抗感染治疗中指导抗生素的应用,其为观察组,通过临床病情以及患者的症状来控制抗生素的使用,其为对照组,每组40例,对两组患者的治疗时间、抗菌药物的费用、住院费用、住院时间进行比较,对两组患者的C-反应蛋白水平(CRP)、血沉情况(ESR)进行比较,对血清降钙素原的应用价值进行分析,从而作为临床中老年心衰合并肺炎患者的抗感染治疗的治疗依据.结果观察组患者的治疗时间、抗菌药物费用、住院费用、住院时间为(9.5±3.2)d、(2598±361)元、(5829±669)元、(13.0±4.1)d,均明显优良于对照组患者的(17.1±4.5)d、(3854±439)元、(9981±687)元、(15.6±2.5)d,组间差异有统计学意义(t=6.4813、5.4712、6.5872、6.4938,P<0.05);观察组患者的CRP水平为改善效果更加显著,差异有统计学意义(t=7.4857,7.9612,P<0.05).结论老年心衰合并肺炎患者通过检查血清降钙素原的水平,在抗感染治疗中可以对抗生素的用量进行控制,增加抗感染治疗的治疗效果,减少治疗费用,降低患者经济压力,有效改善患者的治疗指标,值得在临床中得到广泛推广和应用.

Objective To control the level of antibiotics in patients with senile heart failure and pneumonia through anti-infective treatment, and to analyze the therapeutic indicators of patients and evaluate the therapeutic value of serum procalcitonin. Methods In this study, a total of 80 patients with senile heart failure and pneumonia admitted to our hospital from January 2016 to March 2018 were selected. According to whether to take serum procalcitonin for symptomatic treatment, they were divided into the observation group (n=40, through the serum procalcitonin level in the anti-infective treatment) and the control group (n=40, through the clinical condition and the symptoms of the patient to control the use of antibiotics). The treatment time, antibiotic cost, hospitalization cost, and hospitalization time of the two groups were compared. C-reactive protein levels (CRP) and erythrocyte sedimentation rate (ESR) were compared between the two groups, and the application of serum procalcitonin was performed. The value was analyzed to serve as a basis for the treatment of anti-infective treatment in patients with clinically senile heart failure and pneumonia. Results The treatment time, antibacterial cost, hospitalization cost, and hospitalization time of the observation group were (9.5±3.2)d,(2 598±361)yuan,(5 829±669)yuan,(13.0±4.1)d, which were significantly better than those in the control group (17.1±4.5)d,(3 854±439)yuan,(9 981±687)yuan,(15.6±2.5)d, and the difference between the groups was statistically significant(t=6.481 3, 5.471 2, 6.587 2, 6.493 8,P<0.05). The improvement of CRP level of the observation group was more significant, and the difference between the two groups was statistically significant(t=7.485 7, 7.961 2,P<0.05). Conclusion Examining serum procalcitonin levels in the treatment of the patients with senile heart failure and pneumonia can guide dosage of antibiotics in anti-infective treatment, improve the therapeutic effect of anti-infective treatment , reduce the treatment cost and the economic pressure, and effectively improve therapeutic index of patients, which is worth widely popularization and application in clinical practice.