鱼腥草滴眼液联合玻璃酸钠滴眼液在干眼患者白内障术后中的应用效果

Application of Houttuynia Eyedrops Combined with Sodium Hyaluronate Eyedrops in Dry Eye Patients after Cataract Surgery

目的:探讨鱼腥草滴眼液联合玻璃酸钠滴眼液在干眼患者白内障超声乳化术后中的应用效果。方法:选取术前存在干眼症状接受白内障超声乳化术的患者90例(90只眼),按照随机数字表法将其分为观察组和对照组,各45例。两组术后均常规给予妥布霉素地塞米松滴眼液,在此基础上,观察组接受鱼腥草滴眼液联合玻璃酸钠滴眼液治疗,对照组仅接受玻璃酸钠滴眼液治疗,8周为一疗程。对比两组治疗前后眼表疾病指数(OSDI)评分、泪膜破裂时间(TBUT)、角膜荧光素染色评分和泪液分泌(SehirmerⅠ)试验,观察治疗8周后两组干眼患病率、泪液中炎症细胞因子(IL-1β、TNF-α)水平,记录两组治疗期间不良反应发生情况。结果:治疗8周,观察组OSDI评分、TBUT、荧光素染色评分和SehirmerⅠ试验均优于对照组(P<0.05);治疗8周时,观察组干眼患病率低于对照组(P<0.05),观察组泪液中IL-1β、TNF-α水平均低于对照组(P<0.05);两组治疗期间,均未见明显不良反应发生。结论:对于术前存在干眼症状的白内障患者,鱼腥草滴眼液联合玻璃酸钠滴眼液可以进一步改善白内障超声乳化术后干眼症状和体征,可能与减轻炎症反应有关。

Objective:To investigate the effect of Houttuynia Eyedrops combined with Sodium Hyaluronate Eyedrops on dry eye patients after phacoemulsification.Method:A total of 90 patients(90 eyes)with dry eye symptoms before cataract phacoemulsification were selected.According to the random number table method,they were divided into observation group and control group,45 cases in each group.Both groups were routinely given Tobramycin Dexamethasone Eyedrops after operation,on this basis,the observation group received Houttuynia Eyedrops combined with Sodium Hyaluronate Eyedrops,while control group received only Sodium Hyaluronate Eyedrops,8 weeks as a course of treatment.The ocular surface disease index(OSDI)score,tear film rupture time(TBUT),corneal fluorescein staining score and tear secretion(Sehirmer Ⅰ)test before and after treatment between two groups were compared,after 8 weeks of treatment,the incidence of dry eye and the levels of inflammatory cytokines(IL-1β,TNF-α)in tear of two groups were observed,and the occurrence of adverse reactions during treatment was recorded.Result:After 8 weeks of treatment,the OSDI score,TBUT,fluorescein staining score and Sehirmer Ⅰ test in observation group were better than those of control group(P<0.05).At 8 weeks of treatment,the incidence of dry eye in observation group was lower than that of control group(P<0.05),the levels of IL-1β,TNF-αin tear of observation group were lower than those of control group(P<0.05).During the treatment period,no obvious adverse reactions occurred in both groups.Conclusion:For cataract patients with dry eye before operation,Houttuynia Eyedrops combined with Sodium Hyaluronate Eyedrops can further improve dry eye symptoms and signs after phacoemulsification,which may be related to alleviating inflammation.