血清IL-31表达水平与慢性自发性荨麻疹患者病变严重程度、瘙痒程度和生活质量的相关性研究

The correlation between serum IL-31 expression level and severity, pruritus and quality of life in patients with chronic spontaneous urticaria

目的探讨血清IL-31水平与慢性自发性荨麻疹病变严重程度、瘙痒程度和生活质量的相关性。方法选取2015年12月-2018年12月余姚市人民医院皮肤科收治的180例慢性自发性荨麻疹患者和同期60例健康体检者为研究对象,根据患者病情,将患者分为轻度组(60例)、中度组(60例)和重度组(60例),比较各组患者血清IL-31水平差异情况,对患者进行7 d综合症状积分、VAS和CU-Q2oL评分。统计分析患者血清IL-31水平与7 d综合症状积分、VAS评分和CU-Q2oL评分之间的相关性。结果健康体检者血清IL-31水平为(7.63±0.85)pg/mL,显著低于慢性自发性荨麻疹患者水平[(25.14±3.50)pg/mL,P<0.05]。轻度组、中度组和重度组患者血清IL-31水平依次增高[(17.66±2.05)pg/mL、(23.70±3.13)pg/mL和(28.77±3.62)pg/mL],差异具有统计学意义(P<0.05)。Person相关性分析显示,血清IL-31水平与慢性自发性荨麻疹患者7 d综合症状积分、VAS评分和CU-Q2oL评分均呈正相关性(r=0.658~0.795,P=0.008~0.020)。结论 IL-31在慢性自发性荨麻疹患者的致痒机制中可能具有重要作用,对病变的严重程度和患病后的生活质量均有影响。

Objective To investigate the correlation between serum IL-31 expression level and severity, pruritus and quality of life in patients with chronic spontaneous urticaria. Methods A total 180 patients with chronic spontaneous urticaria and 60 health examinees admitted to dermatology department of our hospital from December 2015 to December 2018 were selected as the research objects. According to the patient’s condition, the patients were divided into mild group(60 cases), moderate group(60 cases) and severe group(60 cases). The difference of serum IL-31 levels in each group was compared. The patients were scored with 7-day comprehensive symptom score, VAS and CU-Q2 oL score. The correlation between serum IL-31 level and 7 d symptom score, VAS score and CU-Q2 oL score was tested. Results The serum level of IL-31 in healthy subjects(7.63±0.85) pg/mL was significantly lower than that in patients with chronic spontaneous urticaria(25.14±3.50) pg/mL(P<0.05). The serum IL-31 levels in the mild, moderate and severe groups increased in turn Serum IL-31 levels in mild, moderate and severe groups increased in turn(17.66±2.05, 23.70±3.13 and 28.77±3.62) pg/mL, with statistical significance(P<0.05). Person correlation analysis showed that serum IL-31 level was positively correlated with 7-day syndrome score, VAS score and CU-Q2 oL score in patients with chronic spontaneous urticaria(r=0.658-0.795, all P<0.05). Conclusion IL-31 may play an important role in the itching mechanism of patients with chronic spontaneous urticaria, and may affect the severity of the lesion and the quality of life after the disease.