超声电导透皮给药治疗支气管扩张合并感染临床观察

Clinical Observation of Ultrasound Conductance Transdermal Administration in the Treatment of Bronchiectasis combined with Infection

目的探讨超声电导透皮给药治疗支气管扩张合并感染的临床疗效和不良反应。方法选取2018年1月—2019年1月收治的支气管扩张合并感染患者94例,根据随机数字表法分为观察组(47例)和对照组(47例),观察组患者通过超声电导透皮给药盐酸氨溴索,对照组使用静脉注射给药,治疗5~7d。比较两组患者临床疗效、症状缓解时间和住院时间,以及不良反应发生率。结果观察组有效率显著高于对照组(Х^2=6.021,P<0.05),观察组发热、咳嗽、喘憋、肺部啰音症状改善时间显著小于对照组(P<0.05),观察组住院时间显著小于对照组(t=8.685,P<0.05),观察组不良反应发生率显著低于对照组(Х^2=5.595,P<0.05)。结论采用超声电导透皮给药治疗支气管扩张合并感染的临床疗效显著优于静脉注射给药,尤其在改善痰量、痰的性状、咳痰难度、肺部啰音的临床症状方面,可有效提高临床疗效,减少不良反应发生率。

Objective To explore the clinical efficacy and adverse reactions of ultrasound conductance transdermal administration in the treatment of bronchiectasis combined with infection.Methods Ninety-four patients with bronchiectasis complicated with infection admitted to our hospital from January 2018 to January 2019 were divided into observation group and control group(47 cases in each group)according to the random number table.Ambroxol hydrochloride was administered by transdermal ultrasound conductance in the observation group and by intravenous injection in the control group.After treatment for 5 to 7 days,the clinical efficacy,symptom relief time,hospitalization time and incidence of adverse reactions were compared between the two groups.Results The effective rate of the observation group was significantly higher than that of the control group(Х^2=6.021,P<0.05).The improvement time of fever,cough,wheezing and pulmonary wheezing in the observation group was significantly shorter than that in the control group(P<0.05).The hospitalization time in the observation group was significantly shorter than that in the control group(t=8.685,P<0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group(Х^2=5.595,P<0.05).Conclusion Ultrasound conductance transdermal administration is superior to intravenous drug delivery in the treatment of bronchiectasis with infection,especially in the improvement of sputum volume,sputum characteristics,difficulty of expectoration and clinical symptoms of lung rale.It can effectively improve the clinical efficacy and reduce the incidence of adverse reactions.