双相情感障碍患者治疗前后血清尿酸水平变化

Changes of Serum Uric Acid Level in Patients with Bipolar Affective Disorder before and after Treatment

目的探讨血清尿酸(uric acid,UA)水平在双相情感障碍患者中的变化及其临床意义。方法纳入双相情感障碍患者104例,分别于入院时和入院后8周测定其血清UA水平,采用杨氏躁狂量表(Young ManiaRatingScale,YMRS)和汉密尔顿抑郁量表(HAMD)评估其症状及病情严重程度,同时纳入健康者72例作对照。结果双相情感障碍组血清UA水平[(461.59±60.40)μmol/L]高于健康对照组[(283.13±56.73)μmol/L],差异有高度统计学意义(P<0.01);双相情感障碍组治疗前的血清UA水平[(461.59±60.40)μmol/L]高于其治疗8周后UA水平[(421.15±60.10)μmol/L],差异有高度统计学意义(P<0.01)。结论双相情感障碍患者血清UA水平升高,且血清UA水平升高可能是双相情感障碍的生物学标记物之一,经治疗后,双相情感障碍患者尿酸水平下降可以作为反映其预后的一项指标。

Objective To investigate the changes and clinical significance of serum uric acid(uric acid,UA)level in patients with bipolar affective disorder.Methods 104 patients with bipolar disorder were included,and the serum levels of UA were measured at the time of admission and 8 weeks after admission,Young Mania Rating Scale(YMRS)and Hamilton depression scale(HAMD)were used to assess the symptoms and severity of the disease.Results The serum UA level of the bipolar disorder group significantly higher than that of the control group[(461.59±60.40)mol/L]vs.(283.13±56.73)mol/L](P<0.01).The serum UA level was higher than that of the 8 weeks after the treatment of uric acid level[(461.59±60.40)mol/L vs.(421.15±60.10)mol/L](P<0.01).Conclusion Elevated serum UA level and elevated serum UA level in bipolar disorder may be a biomarker for bipolar disorder.After treatment,the decrease of uric acid level in bipolar disorder can be used as an indicator of prognosis.