尿微量白蛋白联合肾脏超声在糖尿病肾病中医辨证分型中的应用

Application of Microalbuminuria combined with Renal Ultrasonography in TCM Syndrome Differentiation of Diabetic Nephropathy

目的:观察尿微量白蛋白联合肾脏超声与糖尿病肾病中医辨证分型的相关性,为糖尿病肾病中医辨证客观化提供依据。方法:根据中医证型将135例糖尿病肾病患者分为4组,分别测定每组患者尿微量白蛋白、肾体积、肾段间叶动脉收缩期峰值血流速度(VS),并计算阻力指数(RI)。结果:阴虚燥热证患者的尿微量白蛋白、肾体积、VS、RI与其余3组比较,差异有统计学意义(P<0.05);阴阳两虚证患者的尿微量白蛋白、VS、RI与其余3组比较,差异有统计学意义(P<0.05);气阴两虚证患者RI与脾肾气虚证比较,差异有统计学意义(P<0.05);尿微量白蛋白与VS相关性良好(r=-0.613,P<0.05)。结论:尿微量白蛋白联合肾脏超声中VS可作为糖尿病肾病中医辨证分型的客观化指标。

Objective: To observe the difference and correlation between microalbuminuria(MAU) combined with renal ultrasonography and the syndrome differentiation of traditional Chinese medicine in diabetic nephropathy(DN), and to provide the basis for the objective of TCM syndrome differentiation of DN. Method: According to different TCM syndrome types, 135 patients with DN were divided into 4 groups, MAU, renal volume and VS were measured respectively, and RI was calculate. Results: The MAU, kidney volume, VS, RI of the patients with Yin deficiency and dryness-heat syndrome were significantly different with the other three groups(P<0.05).The MAU, VS, RI of the patients with Yin-Yang deficiency syndrome were significantly different with the other three groups(P<0.05). The RI of the patients with Qi-Yin deficiency syndrome were significantly different with spleen-kidney qi deficiency syndrome(P<0.05). The correlation between MAU and VS was statistically significant(r=-0.613, P<0.05). Conclusion: MAU combined with renal ultrasonography can be used as an objective index of TCM syndrome differentiation of DN.