半夏泻心汤的工艺改进及药效研究

Technology Improvement and Pharmacology of Banxiaxiexin Tang

半夏泻心汤出自汉代著名医家张仲景的经典古方,目前在临床上依然被广泛用于治疗胃炎胃溃疡,本研究对处方用量进行调整,并采用乙醇提取、大孔树脂纯化的方法进行工艺改进,获得4种提取组分,通过对其进行胃溃疡的抑制作用、抗炎作用、以及对幽门螺杆菌感染的治疗作用等药效研究,筛选出药效最强的分离部位,试验结果显示,采用质量分数为40%乙醇提取,并通过AB-8大孔树脂富集,5倍量树脂体积的40%乙醇洗脱得到的分离部位对抑制胃溃疡、抗炎以及杀灭幽门螺杆菌的作用最强,故提取分离该有效部位,用于治疗胃炎、胃溃疡,可最大限度的减少患者服用量,保留有效成分,为将古方制备成方便服用、质量可控、易保存的现代制剂提供技术及理论基础。

The macroporous resin was applied in the improved purification process of Banxia XiexinTang,a classical ancient prescription. Four kinds of extracting components have been obtained. With the examination on the inhibiting effect on gastrohelcosis,anti-inflammatory action and the therapeutic action on helicobacter pylori infection,the most effective part has been screen out. The results show that the separation part eluted by40% ethanol and enriched by AB-8 resin and 40% ethanol extraction solution presents superior therapeutic performances on gastritis and gastrohelcosis due to the maximum retention of effective ingredients and the minimum dosage. This improved technology provides the technical and theoretical basis for the modern pharmaceutical technology to transform the classical ancient prescriptionin to a convenient and qualitycontrollable medicine.