流程化护理干预在37例CD20阳性B细胞淋巴瘤患者常规化疗联合靶向药物治疗中的应用

Application of process nursing intervention in 37 cases of CD20 positive and B cell lymphoma treated with conventional chemotherapy combined with targeted drug therapy

目的探讨流程化护理干预在CD20阳性B细胞淋巴瘤患者常规化疗联合靶向药物治疗中的应用价值.方法选取该院2015年6月~2017年12月CD20阳性B细胞淋巴瘤患者74例,依据建档顺序分为研究组与对照组,各37例.两组均采取常规化疗联合靶向药物(利妥昔单抗)治疗,治疗期间对照组采取常规护理,研究组于常规护理基础上采取流程化护理干预.统计两组治疗情况、不良反应发生率、干预前后负性情绪[抑郁(SDS)、焦虑(SAS)]分值、护理满意度.结果研究组靶向药物首次滴注成功率(64.86%)与对照组(59.46%)间比较,差异无统计学意义(P>0.05),研究组治疗方案完成率(97.30%)高于对照组(78.38%),差异有统计学意义(P<0.05);研究组不良反应发生率(13.51%)低于对照组(27.03%),差异有统计学意义(P>0.05);干预后两组SDS及SAS分值较干预前降低,且研究组低于对照组,差异无统计学意义(P<0.05);研究组护理满意度(94.59%)高于对照组(75.68%),差异有统计学意义(P<0.05).结论CD20阳性B细胞淋巴瘤患者常规化疗联合靶向药物治疗期间采取流程化护理干预,可有效提高靶向药物首次滴注成功率及治疗方案完成率,缓解患者负性情绪,减少药物所致不良反应,且可提高护理满意度.

Objective To investigate the application value of process nursing intervention in the treatment of patients with CD20 positive and B cell lymphoma treated with conventional chemotherapy combined with targeted drug therapy. Methods A total of 74 cases of CD20 positive and B cell lymphoma in our hospital from June 2015 to December 2017 were selected and divided into the study groupand the control groupaccording to the archiving order, 37 cases of each group.The two groups were treated with conventional chemotherapy combined with targeted drugs (rituximab). During the treatment, the control group was cared by routine nursing, and the study group was cared by the process nursing intervention on the basis of routine nursing.The treatment conditions, the incidence of adverse reactions, scores of negative emotion [depression (SDS), anxiety (SAS)] before and after intervention, and nursing satisfaction of two groups were measured. Results There were insignificant differences in the success rate of target drug infusion for the first time between the study group (64.86%) and the control group (59.46%)(P>0.05). The completion rate of the treatment program in the study group (97.30%) was higher than that in the control group (78.38%), and the difference was statistically significant(P<0.05). The incidence of adverse reactions in the study group (13.51%) was lower than that in the control group (27.03%), and the difference was statistically significant(P<0.05). After intervention, the scores of SDS and SAS of two groups were lower than those before intervention, and the study group was lower than the control group, and the difference was statistically significant(P<0.05). The nursing satisfaction of the study group (94.59%) was higher than that of the control group (75.68%), and the difference was statistically significant(P<0.05). Conclusions Process nursing intervention in patients with CD20 positive and B cell lymphoma treated with conventional chemotherapy combined with targeted drug therapy can effectively improve the success rate of the first infusion of target drugs and the completion rate of treatment plan, relieve the negative emotions of patients, reduce the adverse reactions caused by drugs, and improve the satisfaction degree of nursing.