大黄蛰虫胶囊联合介入疗法治疗输卵管阻塞性不孕症的临床观察

Clinical Observation on Treatment of Fallopian Tube Obstructive Infertility with Rhubarb Aphid Capsule Combined with Interventional Therapy

目的观察大黄蛰虫胶囊联合介入疗法治疗输卵管阻塞性不孕症的临床疗效及作用机制。方法将60例输卵管阻塞患者随机分为观察组和对照组,每组各30例。治疗组采用大黄蛰虫胶囊联合介入疗法治疗,对照组采用介入疗法抗感染治疗。结果治疗组有效率为92.67%,对照组有效率为82.67%,两组比较差异有统计学意义(P<0.05));治疗一年后,观察组再通率、妊娠率明显高于对照组,再闭塞率低于对照组,差异有统计学意义(P<0.05);治疗后观察组患者IL-6、hs-CRP和TNF-α均低于对照组,两组治疗后均低于治疗前,差异有统计学意义(P<0.05)。结论大黄蛰虫胶囊联合介入疗法可以显著改善输卵管通畅水平,提高患者妊娠率。

OBJECTIVE To observe the clinical efficacy and mechanism of rhubarb aphid capsule combined with interventional therapy for tubal obstruction infertility. METHODS 60 patients with tubal obstruction were randomly divided into observation group and control group(30 cases for each group). The treatment group were treated with rhubarb aphid capsule combined with interventional therapy,and the control group were treated with interventional therapy for anti-infective treatment. RESULTS The effective rate was 92.67% in treatment group and 82.67% in control group. The difference between these two groups was statistically significant(P<0.05). After 1 year of treatment,the recanalization rate and pregnancy rate of observation group were significantly higher than those of control group. The reocclusion rate was lower than control group,and the difference was statistically significant(P<0.05). After treatment,IL-6,hs-CRP and TNF-α in the observation group were lower than the control group after treatment. The difference between the two groups was lower than that before treatment(P<0.05). CONCLUSION Rhubarb aphid capsule combined with interventional therapy could significantly improve the fallopian tube patency and improve the pregnancy rate of patients.