摘要
目的研究铁牛七Aconitum szechenyianum Gay.的化学成分。方法铁牛七80%乙醇提取物采用正相硅胶、半制备高效液相色谱柱进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到7个化合物,分别鉴定为8-O-methylaconine(1)、8-O-ethyl-aconine(2)、8-O-ethyl-14-benzoylmesaconine(3)、苯甲酰乌头原碱(4)、N-甲基苯甲酰胺(5)、β-谷甾醇(6)、棕榈酸(7)。结论化合物1~4为首次从该植物中分离得到。
AIM To study the chemical constituents from Aconitum szechenyianum Gay.. METHODS The 80% ethanol extract from A. szechenyianum was isolated and purified by silica and semi-preparative HPLC column, then the structures of obtained compounds were identified by physicochemical properties and spectral data. RESULTS Seven compounds were isolated and identified as 8-O-methylaconine ( 1),8-O-ethylaconine ( 2),8- O-ethyl-14-benzoylmesaconine ( 3),benzoylaconine ( 4),N-methyl benzamide ( 5),β-sitosterol ( 6),palmitic acid ( 7). CONCLUSION Compounds 1-4 are isolated from this plant for the first time.
作者
宋蓓
王菲
李玉泽
张化为
黄文丽
李翠
宋小妹
刘建利
SONG Bei;WANG Fei;LI Yu-ze;ZHANG Hua-wei;HUANG Wen-li;LI Cui;SONG Xiao-mei;LIU Jian-li(The Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712046,China;The College of Life Sciences,Northwest University,Xi’an 710069,China;Shaanxi Institute for Food and Drug Control,Xi’an 710065,China;School of Pharmacy,Shaanxi University of Chinese Medicine,Xianyang 712046,China)
出处
《中成药》
CAS
CSCD
北大核心
2019年第8期1871-1875,共5页
Chinese Traditional Patent Medicine
基金
国家自然科学基金资助项目(81102805,81373978)
陕西省教育厅资助项目(15JK1204)
陕西中医药大学学科创新团队项目(2019-YL12)
关键词
铁牛七
化学成分
分离鉴定
Aconitum szechenyianum Gay.
chemical constituents
isolation and identification
