自拟调经汤治疗原发性痛经的临床研究

Clinical Study of Self-made Tiaojing Decoction in the Treatment of Primary Dysmenorrhea

目的 探讨自拟调经汤对原发性痛经患者临床疗效及血清组氨酸(HIS)、前列腺素E2(PGE2)、前列腺素F2α(PGF2α)水平的影响。方法 选取2017年4月—2018年3月本院妇产科收治的原发性痛经患者98例,按照随机数字表法分为观察组和对照组,每组49例。对照组患者予以布洛芬缓释胶囊口服,观察组患者在对照组治疗基础上联合自拟调经汤口服。连续治疗2个月后,比较2组患者临床疗效、痛经程度评分及血清HIS、PGE2、PGF2α水平变化。结果 治疗后,观察组临床治疗总有效率为95.92%,显著高于对照组的81.63%(P<0.05);2组患者痛经程度积分、血清HIS及PGF2α水平均较治疗前明显下降,血清PGE2水平均较治疗前明显升高,且观察组改善程度显著优于对照组(P<0.05)。结论 原发性痛经患者采用自拟调经汤治疗可有效提升临床疗效,缓解痛经症状,改善血清HIS、PGE2及PGF2α水平,值得临床推广应用。

Objective To investigate the effect of self-made Tiaojing decoction on clinical efficacy and serum histidine(HIS),prostaglandin E 2(PGE2),prostaglandin F 2α(PGF2α) levels in patients with primary dysmenorrhea. Methods From April 2017 to March 2018,ninety-eight patients with primary dysmenorrhea were selected and randomly divided into observation group and control group according to random digital table method,with 49 cases in each group.The patients in the control group were treated with ibuprofen sustained release capsule,and the patients in the observation group were treated with self-made Tiaojing decoction on the basis of the control group.After 2 months of continuous treatment,the clinical efficacy,dysmenorrhea degree score and serum HIS,PGE2,PGF2α levels were compared between the two groups. Results After treatment,the total effective rate of clinical treatment in the observation group was 95.92%,which was significantly higher than that in the control group(81.63%)( P <0.05).The score of dysmenorrhea degree,the levels of serum HIS and PGF2α in the two groups were significantly lower than those before treatment,the levels of serum PGE2 in the two groups were significantly higher than those before treatment,and the improvement degree in the observation group was significantly better than that in the control group( P <0.05). Conclusion The treatment of primary dysmenorrhea patients with self-made Tiaojing decoction could effectively improve the clinical efficacy,relieve dysmenorrhea symptom and improve the levels of serum HIS,PGE2 and PGF 2α.It is worth popularizing and applying in clinic.