HBV相关慢加急性肝衰竭患者血清自噬相关蛋白的表达及意义

Expression and significance of serum autophagy-related protein in patients with HBV-related acute-on-chronic liver failure

目的探讨自噬相关蛋白(Beclin1)在HBV相关慢加急性肝衰竭(HBV-ACLF)患者外周血中的表达水平及意义。方法将20例HBV-ACLF患者(HBV-ACLF组),20例慢性乙型肝炎(CHB)患者(CHB组)和20例健康志愿者(健康组)作为研究对象。检测3组血清Beclin1、总胆红素、白蛋白水平,分析血清Beclin1水平与总胆红素、白蛋白水平的相关性。结果HBV-ACLF组患者血清Beclin1、总胆红素水平均高于健康组和CHB组,而血清白蛋白水平低于健康组和CHB组(均P<0.05);Pearson相关分析结果显示,Beclin1与总胆红素水平呈正相关,与白蛋白水平呈负相关(均P<0.05)。结论HBV-ACLF患者血清Beclin1表达水平升高,这可能与HBV-ACLF的发生发展有关。Beclin1或可作为HBV相关慢性肝病病情严重程度的预测指标。

Objective To investigate the expression level and significance of peripheral blood autophagy-related protein(Beclin1) in patients with HBV-related acute-on-chronic liver failure(HBV-ACLF). Methods Twenty patients with HBV-ACLF(HBV-ACLF group),20 patients with chronic hepatitis B(CHB)(CHB group),and 20 health y volunteers(healthy group) were enrolled as subjects.Serum Beclin1,total bilirubin and albumin levels were detected in the three groups,and the correlation of serum Beclin1 level with total bilirubin and albumin levels was analyzed . Results Patients in the HBV-ACLF group had higher serum Beclin1 and total bilirubin levels and a lower serum albumin level compared with the healthy group and the CHB group(all P <0.05);Pearson correlation analysis results showed that Beclin1 positively correlated with total bilirubin level and negatively correlated with albumin level(all P <0.05). Conclusion Elevated expression level of serum Beclin1 is observed in patients with HBV-ACLF,which may be associated with the occurrence and development of HBV-ACLF.Beclin1 may serve as a predictor for severity of HBV-related chronic liver diseases.