慢性阻塞性肺疾病急性加重患者体质量指数与病情的相关分析

Correlation Analysis between Body Mass Index and Disease Status in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的根据慢性阻塞性肺疾病急性加重(AECOPD)患者体质量指数(BMI)对患者进行分层,探讨BMI与患者急性发作期病情的相关性。方法回顾分析我院596例AECOPD患者临床资料,根据BMI指数将患者分成低体质量、正常体质量、超重、肥胖4组,分析患者各项临床指标(年龄、性别、吸烟、生化指标、肺功能、有创呼吸机使用率、病死率、住院时间、住院费用等)与BMI的关系。结果 BMI与患者年龄呈负相关(P=0.04);BMI越低,吸烟患者比例越高,吸烟量越大。logistic回归分析表明,BMI低是患者C反应蛋白水平、FEV1/FVC、住院时间及住院费用的影响因素(均P <0.05)。结论 AECOPD患者中超重和肥胖比例低于正常人群。BMI低的AECOPD患者病情较重。

Objective Patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD) were stratified according to body mass index(BMI),and the correlation between BMI and the patients condition was investigated. Methods A total of 596 patients were retrospectively analyzed. BMI was calculated,and the patients were divided into four groups according to BMI as follows:underweight,normal weight,overweight,and obesity. The relationship of the patients BMI with age,sex,smoking condition,laboratory parameters,lung function,invasive ventilator use rate,mortality,hospitalization time,and hospitalization expenses of the four groups were analyzed. Results The underweight,normal weight,overweight,and obesity groups accounted for 19.6%,47.1%,23.2%,and 9.9% of the patients,respectively. BMI negatively correlated with patient age(P = 0.05). The lower the BMI,the higher the proportion of smokers and the greater the amount of smoking in the patients. In a logistic analysis,we found that lower BMI is an important influencing factor of C reactive protein level,forced expiratory volume in 1 s to forced vital capacity,hospitalization time,and hospitalization expense(P < 0.05).Conclusion The proportions of subjects who are overweight and obese among the AECOPD patients are lower than those among the healthy population. The patients with lower BMI have significantly more severe COPD.