甲巯咪唑治疗甲状腺功能亢进症的疗效及安全性分析

Safety and efficacy of Methimazole in the treatment of hyperthyroidism

目的研究甲巯咪唑治疗甲状腺功能亢进症的临床效果及安全性。方法将2018年9月—2019年3月我院收治的甲状腺功能亢进症患者60例进行随机分组,分为试验组30例和对照组30例,分别使用甲巯咪唑和丙硫氧嘧啶进行治疗,比较2组患者的临床疗效和不良反应。结果试验组临床治疗总有效率为93.33%,明显优于对照组的66.67%(P<0.05);试验组患者血细胞计数减少发生率虽高于对照组,但差异无统计学意义(P>0.05),试验组肝功能指标异常、皮疹和皮肤瘙痒发生率均明显低于对照组,差异具有统计学意义(P<0.05)。治疗前,2组患者游离甲状腺素和总三碘甲状腺原氨酸比较无显著差异(P>0.05),治疗后试验组患者均明显优于对照组,差异有统计学意义(P<0.05)。结论采用甲巯咪唑治疗甲状腺功能亢进症效果显著,可明显降低甲状腺功能指标,且安全性高,值得推广应用。

Objective To study the clinical efficacy and safety of methimazole in the treatment of hyperthyroidism.Methods From September 2018 to March 2019,60 patients with hyperthyroidism were randomly divided into two groups,they were divided into experimental group (methimazole group)30 cases and control group (propylthiouracil group)30 cases. The two groups were treated with methimazole and propylthiouracil respectively. The clinical efficacy and safety of the two groups were compared. Results The total effective rate of clinical treatment in the experimental group was 93.33%,which was significantly better than 66.67% in the control group (P<0.05). The incidence of blood cell count decrease in the experimental group was higher than that in the control group,but there was no significant difference(P>0.05). The incidence of abnormal liver function,rash and pruritus in the experimental group was significantly lower than that in the control group (P<0.05). Before treatment,there was no significant difference in free thyroxine and total triiodothyronine between the two groups (P>0.05),but after treatment,free thyroxine and total triiodothyronine in the experimental group were significantly better than those in the control group,there was significant difference (P<0.05).Conclusion Methimazole is effective in the treatment of hyperthyroidism,which can significantly reduce a series of thyroid indicators,and has high safety,it is worth popularizing and applying.