丹溪痛风方联合小剂量秋水仙碱对急性痛风性关节炎疼痛症状及炎症因子的影响

Effect of Danxi gout party combined with Low-dose colchicine on pain symptoms and inflammatory factors in acute gouty arthritis

目的探讨丹溪痛风方联合小剂量秋水仙碱对急性痛风性关节炎疼痛症状及炎症因子的影响。方法选取84例痛风性关节炎患者,随机分为观察组和对照组各42例。对照组采用小剂量秋水仙碱治疗,观察组在对照组的治疗基础上加用丹溪痛风方治疗,对比2组疼痛视觉模拟评分(VAS)法评分以及C反应蛋白(CRP)、白细胞介素-1(IL-1)、白细胞介素-6(IL-6)的水平。结果观察组治疗后1 d、3 d、1周的疼痛VAS评分均显著低于对照组(P<0.05);观察组治疗后的CRP、IL-1、IL-6水平均显著低于对照组(P<0.05)。结论丹溪痛风方联合小剂量秋水仙碱可迅速缓解急性痛风性关节炎患者的疼痛症状,降低炎症因子水平,提高临床疗效。

Objective To investigate the effect of Danxi gout party combined with low-dose colchicine on pain symptoms and inflammatory factors in acute gouty arthritis. Methods 84 patients with gouty arthritis were randomly divided into observation group and control group with 42 cases in each group. The control group was treated with low-dose colchicine,while the observation group was treated with Danxi gout party on the basis of the control group. The visual analogue scale (VAS)and the levels of C-reactive protein (CRP),interleukin-1 (IL-1)and interleukin-6 (IL-6)were compared between the two groups. Results After 1d,3d,and 1 week treatment,the VAS scores of the observation group were significantly lower than those of the control group (P<0.05). After treatment,the levels of CRP, IL-1 and IL-6 of the observation group were significantly lower than those of the control group (P<0.05). Conclusion Danxi gout party combined with low-dose colchicine can quickly relieve the pain symptoms of acute gouty arthritis, reduce the level of inflammatory factors and improve the clinical efficacy.