解忧汤外洗治疗糖尿病足的临床效果

Clinical effect of external washing of Jieyou Decoction in the treatment of diabetic foot

目的探讨解忧汤外洗治疗糖尿病足的临床效果。方法选择北京市第六医院中医科2016年1月~2017年6月符合中西医诊断标准的糖尿病足患者99例。用随机数字表法以2∶1分为治疗组和对照组,治疗组66例,对照组33例。最终纳入研究的患者共93例,其中治疗组63例,对照组30例。治疗组采用解忧汤外洗治疗;对照组使用5%艾利克聚维酮碘溶液,按1∶5稀释液3000mL外洗治疗。比较两组的疗效、不同时间点创面愈合率及不良反应发生情况,随访半年观察两组Wagner分级4~5级的发生率。结果治疗组的疗效显著优于对照组,差异有高度统计学意义(P<0.01)。两组患者第2周和第4周的创面愈合率比较差异无统计学意义(P>0.05);而治疗组第6周和第8周的创面愈合率均显著高于对照组,差异有统计学意义(P<0.05)。随访半年,对照组Wagner分级4~5级发生率均显著高于治疗组,差异有统计学意义(P<0.05)。治疗过程中未见明显不良反应。结论解忧汤外洗治疗对糖尿病足具有明显的愈合创面作用,并能够有效控制糖尿病足溃疡的发展。

Objective To explore the clinical effect of external washing of Jieyou Decoction in the treatment of diabetic foot.Methods Total of 99 cases of patients with diabetic foot met with the diagnostic criteria of Chinese and Western medicine in Department of Traditional Chinese Medicine of Beijing Sixth Hospital from January 2016 to June 2017 were selected.They were divided into treatment group and control group by 2∶1 through random number table method,with 66 cases in the treatment group and 33 cases in the control group.A total of 93 patients were included in this study,including 63 cases in the treatment group and 30 cases in the control group.The treatment group was taken external washing of Jieyou Decoction,the control group was treated with 5% Elikey Povidone Iodine Solution and washed with a 1∶5 dilution of 3000 mL.The curative effect,wound healing rate at different time points and adverse reactions of the two groups were compared.Followed up for half a year,the incidence of grade 4 to 5 of Wagner grading in the two groups was observed.Results The curative effect of treatment group was better than that of control group,the difference was highly statistically significant (P < 0.01).There was no significant difference of the wound healing rate between the two groups at the 2nd and 4th week (P > 0.05),while the wound healing rates of the treatment group were higher than thoes of the control group at the 6th and 8th week,the differences was statistically significant (P < 0.05).Followed up for half a year,the incidence of grade 4 to 5 of Wagner grading in the control group was higher than the treatment group,the differences were statistically significant (P < 0.05).No obvious adverse reactions were observed during the treatment.Conclusion The external washing of Jieyou Decoction has obvious healing effect for diabetic foot,which can effectively control the development of ulcer of diabetic foot.