注射用丹参多酚酸对缺血性脑卒中患者hs-CRP水平和血液流变参数的影响

Effect of Salvianolate Lyophilized Injection on hs-CRP level and hemorheological parameters in patients with cerebral ischemic stroke

目的观察注射用丹参多酚酸对缺血性脑卒中患者血清超敏C-反应蛋白(hs-CRP)水平和血液流变参数的影响。方法选取2016年1月~2018年12月河北省保定市第一中心医院收治的100例缺血性脑卒中患者作为研究对象,根据随机数字表法将患者分为对照组和观察组,每组各50例。对照组采用常规治疗,观察组在常规治疗基础上应用注射用丹参多酚酸进行治疗。观察两组患者治疗2周后的美国国立卫生研究院卒中量表(NIHSS)评分、血清hs-CRP水平及血液流变参数相关指标的变化。结果治疗后,两组患者NIHSS评分均低于治疗前,且观察组低于对照组,差异有高度统计学意义(P<0.01)。两组患者血清hs-CRP水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。两组患者血浆黏度、全血黏度高切、全血黏度低切、红细胞比容均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论注射用丹参多酚酸可有效改善缺血性脑卒中患者神经受损状况,降低血清hs-CRP水平,调节血液流变参数。

Objective To observe the effect of Salvianolate Lyophilized Injection on the level of hypersensitive C-reactive protein (hs-CRP) and hemorheological parameters in patients with cerebral ischemic stroke.Methods From January 2016 to December 2018,100 patients with cerebral ischemic stroke admitted to the First Central Hospital of Baoding were divided into the control group and the observation group according to the random number table,method with 50 cases in each group.The control group received conventional treatment,and the observation group was treated with Salvianolate Lyophilized Injection on the basis of conventional treatment.Changes in the National Institutes of health stroke scale (NIHSS) score,serum hs-CRP levels,and hemorheological parameters were observed after 2 weeks of treatment.Results After treatment,the NIHSS scores of the two groups were lower than those before treatment,and the NIHSS scores of the observation group were lower than the control group,the differences were highly statistically significant (P < 0.01).The serum hs-CRP levels in the two groups were lower than those before treatment,and the serum hs-CRP levels in the observation group were lower than those in the control group,the differences were highly statistically significant (P < 0.01).The plasma viscosity,whole blood viscosity were high,whole blood viscosity was low,and erythrocyte specific volume were lower than before treatment,and the observation goup was lower than control group and the difference was statistically significant (P < 0.05).Conclusion Salvianolate Lyophilized Injection can effectively improve the neurological damage in patients with ischemic stroke,reduce serum hs-CRP levels and regulate hemorheological parameters.