抑郁症伴自杀的犬尿氨酸通路机制研究进展

Advanced research of kynurenine pathway mechanism in suicide of major depressive disorder

抑郁症是全球重大的慢性、致残性精神疾病之一,预计到2030年其将位居所有疾病负担的首位。抑郁症是一种高患病率、高复发率、高致残率、高自杀率的精神疾病,自杀死亡是该疾病最为严重的后果。在抑郁症患者中,其中枢神经系统及外周血中的炎症因子水平均较高;而对于伴自杀意念或行为的抑郁症患者,其炎症因子水平的升高更为显著。相关研究显示,炎症因子水平的升高与犬尿氨酸代谢通路的失调相关,如神经毒性产物喹啉酸过量、保护性神经产物吡啶甲酸减少等。该文通过综述对犬尿氨酸代谢途径的研究,以期为探索抑郁症伴自杀的生物学标记物提供参考。

Major depressive disorder (MDD) is one of the world′s major chronic and disabling mental diseases. By 2030, MDD is expected to be the top of all the disease burden in the world, with high prevalence, high recurrence rate, high disability rate, and high suicide rate. Suicide is the most serious consequence of MDD. Current studies showed that inflammatory levels in the central nervous system and peripheral blood of patients with MDD were higher, and increased more significantly in depressive patients with suicidal ideation or behavior. Related researches showed that increased levels of inflammatory cytokines were associated with dysregulation of kynurenine metabolic pathway, leading to imbalances in neurometabolites, such as an excess of the neurotoxic product quinolinic acid and a decrease in the protective neuropeptide picolinic acid. This paper reviews kynurenine metabolic pathway, expecting to identify the biomarkers of MDD patients with suicide.