依达拉奉联合尼莫地平序贯疗法对脑出血患者神经功能及血清NSE、OPN、BDNF表达的影响

Effect of edaravone combined with nimodipine sequential therapy on neurological function and expression of serum NSE, OPN and BDNF in patients with cerebral hemorrhage

目的探讨依达拉奉联合尼莫地平序贯疗法对脑出血患者神经功能及血清神经元特异性烯醇化酶(NSE)、骨桥蛋白(OPN)、脑源性神经营养因子(BDNF)表达的影响。方法收集我院自2016年1月~2019年2月收治的76例脑出血患者,按随机数字表法分为两组,各38例。两组均给予神经内科常规综合治疗,对照组加用尼莫地平序贯疗法,观察组在对照组基础上联合依达拉奉治疗。比较两组神经功能、血肿与周围水肿体积及疗效,检测两组血清NSE、OPN、BDNF水平变化情况。结果治疗后,观察组NIHSS评分低于对照组(P<0.01);观察组总有效率为92.11%,高于对照组的73.68%(P<0.05);治疗后,观察组血肿体积与周围水肿体积均小于对照组(P<0.05);治疗后,观察组血清NSE、OPN低于对照组,BDNF高于对照组(P<0.05)。结论依达拉奉联合尼莫地平序贯疗法治疗脑出血效果确切,可显著缩小血肿及其周围水肿体积,解除血肿占位效应,恢复患者神经功能,改善生化指标。

Objective To investigate edaravone combined with nimodipine sequential therapy on neurological function and expression of serum NSE, OPN and BDNF in patients with cerebral hemorrhage. Methods 76 patients with cerebral hemorrhage admitted in our hospital from January 2016 to February 2019 were enrolled in the study. They were divided into two groups according to the random number table, with 38 cases in each group. Both groups were given routine comprehensive treatment of neurology, and the control group was treated with sequential therapy with nimodipine. The observation group was treated with edaravone based on the treatment of the control group. The neurological function,hematoma volume and its surrounding edema, and efficacy were compared between the two groups. The changes of serum NSE, OPN and BDNF levels were detected. Results After treatment, the NIHSS score of the observation group was lower than that of the control group(P<0.01). The total effective rate of the observation group was 92.11%, which was higher than that of the control group(73.68%),(P<0.05). After treatment, the hematoma volume and its surrounding edema volume of the observation group was smaller than that of the control group(P<0.05). After treatment, the serum NSE and OPN of the observation group was lower than that of the control group, and BDNF of the observation group was higher than that of the control group(P<0.05). Conclusion Edaravone combined with nimodipine sequential therapy for the treatment of cerebral hemorrhage is effective, which can significantly reduce the volume of hematoma and its surrounding edema, relieve the hematoma occupying effect, restore the patient’s nerve function, and improve biochemical indicators.