60例成年人直肠电刺激脑诱发电位特点及结果分析

The characters and results of rectal electrical stimulation cerebral evoked potentials in 60 adults

目的探讨正常人直肠电刺激脑诱发电位(CEP)的正常值及波形特征。方法检查者将刺激电极经肛置入受试者直肠内,在头顶部Cz点放置记录电极,参考电极置于前额部Fz点,使用英国Oxford公司肌电诱发电位仪采样分析。结果所有检测对象均记录有直肠电刺激脑诱发电位,各波参数范围分别是:P1波潜伏期(45.55±3.26)ms,N1波(101.71±15.71)ms,P2波(198.35±27.70)ms,P1/N1波幅(5.62±1.58)μV,N1/P2波幅(8.26±2.48)μV。直肠电刺激脑诱发电位各波潜伏期及波幅在性别、年龄分组间比较,差异无统计学意义。经一般线性回归分析发现,在控制年龄分组、性别后,波幅随BMI增加而降低,BMI每增加1 kg/m2,P1/N1波幅平均下降0.234μV(P=0.011),N1/P2波幅平均下降0.320μV(P=0.027)。结论直肠电刺激脑诱发电位提供了一种简单、有效的评估直肠到大脑皮层感觉神经通路的方法。本研究对了解功能性胃肠疾病中的脑肠互动作用具有重要价值。本研究的检测结果及其影响因素分析,可供后续临床研究借鉴。

Objective To investigate the normal range and waveform characteristics of rectal electrical stimulation cerebral evoked potential(CEP) in healthy people. Methods The examiner placed the stimulus electrode in the rectum of the subjects through the anus, the recording electrode at Cz point on the top of the head, the reference electrode at Fz point on the forehead and sampled by Oxford EMP.Results Rectal electrical stimulation cerebral evoked potentials were recorded in all subjects. The waveform parameters are P1 wave latency(45.55±3.26) ms, N1 wave(101.71±15.71) ms, P2 wave(198.35±27.70) ms, P1/N1 amplitude(5.62±1.58)μV, N1/P2 amplitude(8.26±2.48)μV. There was no signi?cant difference in latency and amplitude of the evoked potential waves between sex and age groups. By general linear regression analysis, it was found that the amplitude decreased with the increase of BMI after controlling age group and sex. For each increase of BMI of 1 kg/m2, the amplitude of P1/N1 decreased by 0.234 μV(P=0.011), and the amplitude of N1/P2 decreased by 0.320 μV(P=0.027). Conclusion Rectal electrical stimulation cerebral evoked potentials provides a simple and effective method for evaluating the sensory nerve pathway from rectum to cerebral. This study is of great value in understanding the brain-intestinal interaction in functional gastrointestinal diseases. The results of this study and the analysis of its in?uencing factors can be used for reference in the follow-up clinical research.