高密度脂蛋白亚类分布与动脉粥样硬化的相关性研究

Progress on Association Between High Density Lipoprotein Subclass Distribution and Atherosclerosis

高密度脂蛋白是一种高度异质型脂蛋白(high density lipoprotein,HDL),因其密度、颗粒大小、电荷和组成成分不同,可分为不同的亚类,不同的亚类对动脉粥样硬化(atherosclerosis,AS)的影响和在胆固醇的逆向转运、抗炎、抗氧化过程所发挥的作用均不相同。综述高密度脂蛋白亚类分布与动脉粥样硬化的相关性研究进展,为进一步阐明动脉粥样硬化的发生机制及寻找抗动脉粥样硬化治疗的新的靶点提供参考。

High density lipoprotein is a highly heterogeneous lipoprotein,which has different kinds of subclasses because of the differences in density,particle size,charge and composition. Different kinds of subclasses have different functions in the metabolism of atherosclerosis and reverse cholesterol transportation and anti-inflammatory and antioxidant. In this paper,the research reviewed the association between high density lipoprotein subclasses distribution and atherosclerosis,providing the reference to further clarify the mechanism of atherosclerosis and looking for new targets for anti treatment of atherosclerosis.