摘要
Five new polyhydroxylated furostanol saponins were isolated from the roots and rhizomes of Tupistra chinensis,and their structures were determined as tupistrosides J–N(1–5),together with four known furostanol saponins(6–9),on the basis of physico-chemical properties and spectral analysis.Among them,compounds 3 and 5 showed cytotoxicity against human cancer cell lines SW620 with IC50 values of 72.5±2.4 and 77.3±2.5μmol·L^–1,respectively.Compound 4 showed cytotoxicity against human cancer cell line HepG2 with IC50 value of 88.6±2.1μmol·L^–1.
Five new polyhydroxylated furostanol saponins were isolated from the roots and rhizomes of Tupistra chinensis,and their structures were determined as tupistrosides J–N（1–5）,together with four known furostanol saponins（6–9）,on the basis of physico-chemical properties and spectral analysis.Among them,compounds 3 and 5 showed cytotoxicity against human cancer cell lines SW620 with IC50 values of 72.5±2.4 and 77.3±2.5μmol·L–1,respectively.Compound 4 showed cytotoxicity against human cancer cell line HepG2 with IC50 value of 88.6±2.1μmol·L–1.
基金
supported by the Open Research Fund of Key Laboratory of Basic and New Herbal Medicament Research,Shaanxi university of Chinese medicine(Nos.17JS030 and 2017KF02)
Subject Innovation Team of Shaanxi University of Chinese Medicine(No.2019-YL12)
the Special Project of Shaanxi Province Education Department(No.14JF005)
the National Natural Sciences Foundation of China(No.81503237)
the Key R&D Program of Shaanxi Province(Nos.2018SF-324,2017SF-360 and 2015SF073)
