基于超大人群队列的心脑血管疾病的病因研究进展:国家自然科学基金重大项目阶段性研究成果综述

Chinese cohort study of the etiology of atherosclerotic cardiovascular diseases:findings from a Major Program of the National Natural Science Foundation of China

缺血性心脏病和缺血性脑卒中已经成为威胁我国人群健康的重要的动脉粥样硬化性心血管疾病。环境和遗传因素如何影响这两种疾病仍不完全清楚,且已有的证据多来自西方发达国家人群,并不完全适用于中国人群。重大项目《环境与遗传因素及其交互作用对冠心病和缺血性脑卒中影响的超大型队列研究》以《中国慢性病前瞻性研究》超大型人群队列为基础,目前已经在生物学、行为、环境等暴露因素与疾病的关联研究上取得了重大突破,为制定我国缺血性心血管疾病的防治对策、更新相关疾病防治指南、更有效地识别高危人群提供了中国人群高质量的病因学证据。

Ischemic heart disease and ischemic stroke are posing major burdens to population health in China.The effects of environmental and genetic factors on ischemic heart disease and ischemic stroke are not fully understood.Most of the existing evidence comes from the Western population,which is not equally applicable to Chinese people.We conducted a major program "A prospective Chinese cohort study of environments and genes and their interactions in the etiology of coronary heart disease and ischemic stroke"based on the China Kadoorie Biobank,a large prospective Chinese cohort.The findings of the program provide high-quality etiological evidence of ischemic heart disease and ischemic stroke,which could support the development and revision of disease prevention and treatment guidelines in China.