中国本能行为研究的现状与展望

Current status and prospective of innate behavior research in China

近年来,本能行为成为神经科学研究的前沿和热点。基于国家自然科学基金委员会第222期双清论坛"本能行为研究的前沿与交叉"的研讨成果,本文将从个体维持行为、趋利避害行为、社会群体的本能行为、本能行为相互作用、本能行为异常及相关疾病、本能行为研究新技术等几个方面,总结国内本能行为研究的最新进展。此次双清论坛凝练出"本能行为神经网络的固有结构和工作机理"这一关键科学问题。在未来5~10年时间里本能行为研究有望在以下几方面产生突破性成果:发现觉醒-睡眠转化和维持的结构和机制;揭示本能行为神经网络信息处理低能耗、高能效、强鲁棒的工作原理;形成本能行为工作机制的新假说;发现奖赏和成瘾机制及干预靶点。

In recent years,innate behavior has become the new frontier in neuroscience research.In this review,we integrate state-of-the-art progress in innate behavior research and symposium discussion from the National Natural Science Foundation of China’s 222 th Shuangqing Forum. The frontiers and intersections of innate behavior research are summarized,including the following topics:neural basis of self-sustaining behaviors,neural circuit mechanisms underlying approaching-avoidance behaviors,innate social behaviors,diseases related to malfunction of innate behaviors,and new tools for innate behavior research.The forum participants reached a consensus that the intrinsic anatomical structure and working mechanism of the neural network implicated in innate behavior are a key scientific question.Several areas of potential breakthrough for future research were proposed as well,including wakefulness-sleep switch and maintenance,the working mechanism underlying the low energy consumption,high efficacy and strong robustness of the neural network implicated in innate behavior,novel hypothesis of the working mechanism of innate behavior,and the mechanism and intervention of reward and addition.