脑梗死患者血清CXCL-16、GDF-15、PLA2水平变化及意义

Clinical significance of serum CXCL-16, GDF-15 and PLA2 in patients with cerebral infarction

目的 研究脑梗死患者的血清CXC趋化因子16(CXCL-16)、血清生长分化因子15(GDF-15)、脂蛋白相关磷脂酶A2(PLA2)的水平变化及对脑梗死患者临床诊治的指导意义.方法 选取2016年6月—2017年6月沧州市中心医院98例脑梗死患者为观察组,同期该院进行体检的50例健康志愿者作为对照组.所有受试者于入院时抽血检测各组的CXCL-16、GDF-15、PLA2、C反应蛋白(CRP)水平,综合评价脑梗死患者各项指标的水平变化及对临床诊断的意义.结果 ①观察组患者的CXCL-16、GDF-15、PLA2、CRP水平与对照组比较,差异有统计学意义(P<0.05).②将观察组患者按美国国立卫生院神经功能缺损评分(NIHSS)分组,患者的CXCL16、GDF-15、PLA2水平随着NIHSS分值的增加而升高,组间比较,差异有统计学意义(P<0.05),而各组间的CRP水平差异无统计学意义(P>0.05).③将患者按病灶大小分组,患者的CXCL16、GDF-15、PLA2水平随病灶的增大而升高(P<0.05),而各组间的CRP水平差异无统计学意义(P>0.05).④观察组患者治疗后出院时的CXCL-16、GDF-15、PLA2、CRP水平与对照组比较,差异无统计学意义(P>0.05),观察组患者的这些指标水平降至正常水平.结论 CXCL-16、GDF-15、PLA2水平随患者病情程度的变化而改变,可作为预测脑梗死患者发病、病情评估及判断预后的生物学标志物.

Objective To study the clinical significance of serum CXC-16, Growth differentiation factor serum-15(GDF-15), lipoprotein associated phospholipase A2(PLa2) level in patients with cerebral infarction.Methods A total of 98 patients with cerebral infarction who were admitted in our hospital during June 2016 to June-2017 were enrolled in the observation group, and 50 healthy volunteers were selected as the control group. Serum levels of CXCL16, GDF-15, PLA2, C-reactive protein, and comprehensive evaluation index were recorded. Results The levels of CXCL-16, GDF-15, PLA2 and CRP were higher significantly in the observation group than those in the control group(P < 0.05). CXCL16, GDF-15, and PLA2 were positively correlated with elevated level of National Institutes of Health Stroke score(NIHSS)(P < 0.05). The levels of CXCL16, GDF-15 and PLA2 were positively correlated with increase of lesion size. No obvious difference in levels of CXCL-16, GDF-15, PLA2 or CRP were observed between observation group and control group(P > 0.05). Conclusions The levels of CXCL-16, GDF-15 and PLA2 may be a reliable biomarker for diagnosis and prognosis.