儿童急性T淋巴细胞白血病治疗及预后

Treatment and prognosis of childhood acute T lymphocytic leukemia

儿童急性T淋巴细胞白血病(T-ALL)的无事件生存率(EFS)显著低于急性B淋巴细胞白血病(B-ALL),且T-ALL诱导失败、早期死亡、复发等风险显著高于B-ALL。近年来,各协作组不断调整治疗方案,如使用地塞米松代替泼尼松、应用大剂量甲氨喋呤、监测MRD水平、应用靶向药物等,极大地改善了T-ALL患儿的临床预后。文章综述国内外协作组治疗儿童T-ALL最新临床方案及研究结果。

The event-free survival rate(EFS)of childhood acute T-lymphocytic leukemia(T-ALL)was significantly lower than that of acute B-lymphocytic leukemia(B-ALL),and the risk of induction failure,early death,and recurrence of childhood T-ALL was significantly higher than that of B-ALL.In recent years,various collaborative groups have continuously adjusted treatment options including using dexamethasone instead of prednisone,applying high-dose methotrexate,monitoring MRD levels,and applying targeted drugs,which have greatly improved the clinical prognosis of childhood T-ALL.This article summarizes the proposals and results of different collaborative groups'treatments of childhood T-ALL.