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阿尔茨海默病多模态MRI形态和功能研究进展 被引量:5

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摘要 阿尔茨海默病是一种持续发展但尚无有效治疗方法的慢性神经系统退行性疾病,因此早期诊断进而对其进行早期干预治疗具有重要意义。多模态MRI能够反映脑内形态学及功能学改变情况,是诊断和监测干预效果的重要手段。本文对阿尔茨海默病患者的脑结构、血流灌注、代谢以及功能等MRI改变进行综述,旨在提高对此疾病的早期诊断水平,指导临床实现对疾病的早期干预,进而改善患者的预后。
出处 《放射学实践》 北大核心 2019年第8期930-934,共5页 Radiologic Practice
基金 国家自然科学基金项目(81671646)
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  • 1李淑宇,石峰,蒲放,蒋田仔,谢晟,王荫华.基于MRI海马形状特征的阿尔茨海默病的自动判别[J].中国医学影像技术,2006,22(9):1321-1324. 被引量:2
  • 2Cornett CR, Markesbery WR, Ehmann WD, et al. Imbalances of trace elements related to oxidative damage in Alzheimer's disease brain. Neurotoxicology, 1998,19(3) :339-346.
  • 3Chamberlain R, Reyes D, Curran GL, et al. Comparison of amy loid plaque contrast generated by T2 weighted, T2 ~ -weighted, and susceptibility weighted imaging methods in transgenic mouse models of Alzheimer's disease. Magn Reson Med, 2009, 61 (5) : 1158-1164.
  • 4McKhann G, Drachman D, Folstein M, et al. Clinical diagnosi] of Alzheimer's disease: report of the NINCDS-ADRDA Wor1 Group under the auspices o{ Department of Health and Huma1 S~ivi~2: 9T22k Force on Alzheimer's Disease. Neurology, 1984,31.
  • 5Ding B, Chen KM, Ling HW, et al. Correlation of iron in the hippoeampus with MMSE in patients with Alzheimer's disease. J Magn Reson Imaging, 2009,29(4) :793 798.
  • 6Zhu WZ, Zhong WD, Wang W, et al. Quantitative MR phase corrected imaging to investigate increased brain iron deposition of patients with Alzheimer disease. Radiology, 2009, 253 (2) : 497- 504.
  • 7Bartzokis G, Sultzer D, Cummings J, et al. In vivo evaluation of brain iron in Alzheimer disease using magnetic resonance imaging. Arch Gen Psychiatry, 2000,57(1) :47-53.
  • 8Press DZ, Casement MD, Schenck JE, et al. High-field MRI demonstrates increased brain iron in Alzheimer's disease. Neuro- Biol Aging, 2004,25 : $378 $379.
  • 9Loeffler DA, LeWitt PA, Juneau PL, et al. Increased regional brain concentrations of ceruloplasmin in neurodegenerative disor ders. Brain Research, 1996,738(2) :265-274.
  • 10Pappolla MA, Omar RA, Kim KS, et al. Immunohistochemical evidence of oxidative stress in Alzheimer's disease. Am J Pathol, 1992,140(3) :621 628.

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