摘要
共轭亚油酸(CLA)因在降低体脂沉积中的生物学功能而成为近年来的研究热点。研究显示,CLA对机体脂肪代谢的调控机制具有复杂性,胞内钙离子、G蛋白偶联受体和炎症反应等通路均可介导CLA对脂肪细胞分化、凋亡、脂质合成的调控作用。本文将综述介导CLA调控脂肪代谢的通路及其相关机制,旨在为进一步的CLA介导的抗肥胖机制研究提供参考。
Conjugated linoleic acid(CLA)has been widely studied for its biological functions in reducing body fat deposition in recent years.It showed that the mechanism of CLA in reducing fat deposition is complex.And several signaling pathways mediated the regulation of CLA in adipocyte adipogenesis,apoptosis and lipogenesis,such as the intracellular calcium pathways,G protein-coupled receptors pathways and inflammatory signaling.This review examined the pathways and mechanisms of CLA in mediating lipid metabolism,and aims at providing more evidences for further studies in mediating CLA’s antiobesity mechanism.
作者
伏春燕
张燕
魏祥法
刘雪兰
FU Chunyan;ZHANG Yan;WEI Xiangfa;LIU Xuelan(Poultry Institute,Shandong Academy of Agricultural Science,Ji’nan 250023,China)
出处
《动物营养学报》
CAS
CSCD
北大核心
2019年第8期3456-3462,共7页
CHINESE JOURNAL OF ANIMAL NUTRITION
基金
山东省自然科学基金(ZR2015YL062)
家禽研究所学科团队建设(CXGC2018E11)
山东省农业科学院农业科技创新工程(CXGC2016A04)
关键词
共轭亚油酸
脂肪沉积
分子机制
信号通路
conjugated linoleic acid
fat deposition
molecular mechanism
signaling pathway
