婴幼儿血管瘤生活质量专用量表的信度与效度检验及其临床应用

Measuring reliability and validity of a Chinese mandarin version quality-of-life instrument for infantile hemangioma and its clinical application

目的国内尚没有评价婴幼儿血管瘤患儿生活质量的专用量表(quality-of-life instrument for IH,IH-QOL)。本研究拟对婴幼儿血管瘤生活质量专用量表中文版的信度与效度进行验证,目的在于评价其在中国人群中的适用性。方法研究者译制出婴幼儿血管瘤生活质量专用量表中文版,并使用该版本对婴幼儿血管瘤患儿的生活质量进行调查。计算该中文版Cronbach s α系数,分析其信度与效度,并对影响婴幼儿血管瘤生活质量专用量表评分的因素进行分析。结果本研究共纳入201例婴幼儿血管瘤。婴幼儿血管瘤生活质量专用量表中文版Cronbach s α系数为0.766,说明其具有良好的信度和结构效度。多元线性回归分析显示,IH位置和大小是影响IH-QOL总分的影响因素(P<0.05)。IH位置和大小可以解释的变异占总变异的24.7%。回归分析最终模型有统计学意义(F=4.279 ,P=0.006 )。结论婴幼儿血管瘤生活质量专用量表中文版具有良好的信度与效度,可用于评估我国婴幼儿血管瘤患儿及其父母生活质量。婴幼儿血管瘤瘤体位置及大小是影响其生活质量的因素。

Objective Infantile hemangioma (IH) is a common vascular tumor in children.Improving quality-of-life (QOL) in IH children and their family members is a vital target of therapy.The QOL instrument for IH is an IH-specific questionnaire,but its Chinese mandarin version has not been available yet.Thus a Chinese mandarin version QOL instrument for IH was developed for measuring its reliability and validity in Chinese populations. Methods The Chinese mandarin version QOL instrument for IH was administered to the parents of IH children.And Cronbach s alpha coefficient was calculated.Multivariate linear regression analysis was used for determining the relevant influencing factors of QOL. Results A total of 201 IH children were recruited.The Cronbach s alpha coefficient for the QOL instrument for IH summary scores was 0.766.The results demonstrated its excellent reliability and structural validity.Multivariate linear regression analysis revealed that two major influencing factors of QOL instrument for IH total scores were size and location of hemangioma. Conclusion The reliability and validity has been confirmed for the Chinese mandarin version of QOL instrument for IH.And hemangioma size and location are important influencing factors of QOL in children with IH and their parents.