普萘洛尔影响婴幼儿血管瘤患儿中枢神经系统功能的新进展

Potential effects of propranolol on central nervous system in children with infantile hemangioma

婴幼儿血管瘤(infantile hemangioma,IH)是婴儿期最常见的良性肿瘤,目前β肾上腺素能受体阻滞剂普萘洛尔是IH的主要治疗药物,但是这种亲脂性药物能够透过血脑屏障,可能会对婴幼儿中枢神经系统功能产生潜在影响。本综述将从短期和长期记忆、精神运动功能、睡眠质量和情绪几个方面来阐述普萘洛尔对IH患儿中枢神经系统功能的潜在影响,以期为评估普萘洛尔治疗IH的安全性研究提供方向。

Infantile hemangioma (IH) is the most common benign tumor during infancy.Propranolol,a beta-adrenergic receptor blocker,is a major treatment for IH.However,this lipophilic drug passes through blood-brain barrier (BBB) and may have potential effects on central nervous system in infants.This review mainly describes the potential effect of propranolol on central nervous system,including short/long-term memory,psychomotor function,sleep quality and mood,in IH children and provides rationales for future safety studies of propranolol treatment.