右美托咪定在七氟醚麻醉患儿中的临床疗效观察

Clinical efficacy of dexmedetomidine in children with sevoflurane anesthesia

目的探讨右美托咪定在应用七氟醚麻醉患儿中的临床疗效。方法分析本院接受诊断治疗的85例扁桃体剥离、腺样体吸切手术患儿的临床资料。随机将入选者分为观察组(n=45,右美托咪治疗)和对照组(n=40,不采用右美托咪定治疗)。比较2组患儿基线资料、不同时段心率(HR)、平均动脉压(MAP)、躁动(EA)发生率、疼痛程度量表评分(CHEOPS)、麻醉苏醒期的躁动评分(PAED)、术后不良反应发生率。结果2组患儿基线资料无显著差异(P>0.05)。T1、T2、T3时刻观察组HR值显著高于对照组,MAP水平显著低于对照组(P<0.05);T1、T2时刻观察组EA发生率、PAED及CHEOPS评分显著低于对照组(P<0.05)。观察组术后不良反应发生率显著低于对照组(P<0.01)。结论右美托咪定可有效稳定七氟醚麻醉患者的血流动力学,降低麻醉苏醒期躁动发生率及术后不良反应发生率。

Objective To investigate the clinical efficacy of dexmedetomidine in children with sevoflurane anesthesia.Methods The clinical data of 85 children who underwent tonsillectomy and adenoidectomy were analyzed.The recruited patients were randomly divided into observation group(45 cases,treated by dexmedetomidine)and control group(40 cases,without dexmedetomidine treatment).The baseline data,heart rate(HR)in different time points,mean arterial pressure(MAP),incidence of restlessness(EA),Children Hospital of Eastern Onterin Pain Scale(CHEOPS)score and Pediatric Anesthesia Emergence Delirium Scale(PAED)scores,postoperative incidence of adverse reactions were compared between the two groups.Results There was no significant difference in baseline data between the two groups(P>0.05).The HR value at T 1,T 2 and T 3 of the observation group was significantly higher,and the MAP level was significantly lower than that of the control group(P<0.05);the incidence of EA,PAED and CHEOPS scores of the observation group at T 1 and T 2 were significantly lower than those of the control group(P<0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group(P<0.01).Conclusion Dexmedetomidine can effectively stabilize the hemodynamics of sevoflurane anesthesia patients,reduce the incidence of restlessness during anesthesia recovery and the incidence of adverse reactions after operation.