左旋氨氯地平治疗轻中度高血压患者的临床效果

Clinical efficacy of levamlodipine in the treatment of patients with mild to moderate hypertension

目的探讨左旋氨氯地平治疗轻中度高血压患者的临床疗效。方法将95例轻中度高血压患者按照入院先后顺序分为2组,对照组47例采用氨氯地平治疗,观察组48例采用左旋氨氯地平治疗,评价2组的临床效果。结果治疗后,2组收缩压、舒张压显著低于治疗前,且观察组显著低于对照组(P<0.05);治疗后,2组血管功能指标(中心动脉脉搏压、臂踝脉搏波动传导速度、动态动脉硬化指数、中心动脉反射波增强指数)水平均显著优于治疗前,但2组间无显著差异(P>0.05);观察组的治疗护理总满意率显著高于对照组(P<0.05),不良反应发生率显著低于对照组(P<0.05)。结论采用左旋氨氯地平治疗轻中度高血压,可有效改善患者的血压水平,且应用安全,疗效确切。

Objective To evaluate the clinical efficacy of levamlodipine in the treatment of mild to moderate hypertension.Methods A total of 95 patients with mild to moderate hypertension admitted to the hospital were divided into two groups according to the order of admission.The control group(n=47)was treated by amlodipine and observation group(n=48)was given levamlodipine for treatment.The clinical efficacy of two groups were evaluated.Results The systolic blood pressure and diastolic blood pressure in two groups were significantly reduced after treatment compared to the treatment before,and the obe observation group was lower than control group(P<0.05).After treatment,the vascular function indexes(central arterial pulse pressure,brachial-ankle pulse wave velocity,dynamic arteriosclerosis index,augmentation index of central artery reflex wave)of the two groups were significantly better than treatment before,but there were no significant differences between the two groups(P>0.05);the total nursing satisfaction in the observation group was significantly higher(P<0.05),and the incidence of adverse reactions was significantly lower than that in the control group(P<0.05).Conclusion Levoamlodipine that is a safe and effective in the treatment of mild to moderate hypertension can effectively improve the blood pressure.