胃癌耐药形成中微小RNA作用机制的研究进展

Role of microRNAs in drug resistance of gastric cancer cells

药物治疗是胃癌(gastric cancer,GC)综合治疗中的重要措施,但肿瘤细胞存在的耐药性常导致治疗失败.探讨GC细胞的耐药机制有重要的意义.研究发现微小RNA(microRNA,miRNA)与GC耐药有密切关系.但由于microRNA种类繁多、作用机制复杂、且在临床应用并不广泛,因此有关microRNA与GC耐药的关系还存在很多需要探讨的领域.本文综述了microRNA在GC耐药形成中的作用,对其中存在的问题及今后的进展方向进行了预测.

Drug therapy is an important component of comprehensive treatments for gastric cancer(GC),but drug resistance of cancer cells often leads to treatment failure.It is significant to explore the drug resistance mechanism of GC cells.It has been reported that microRNAs(miRNAs)are closely related to drug resistance in GC.However,there are many kinds of microRNAs,which possess complex mechanisms and are not widely applied in clinical patients,so there are still many areas to be investigated about the relationship between microRNAs and drug resistance in GC.In this review,we review the role of miRNAs in the formation of drug resistance and discuss the existing problems and future directions.