醋酸甲地孕酮在消化道肿瘤患者化疗中的效果

Effect of megestrol acetate in chemotherapy of patients with digestive tract tumor

目的研究醋酸甲地孕酮在消化道肿瘤患者化疗过程中的效果。方法选择2017年3月至2018年4月在我院接受化疗的消化道肿瘤患者74例为研究对象,采用电脑随机数法分为观察组和对照组,各37例。两组患者均开展常规化疗,观察组患者接受醋酸甲地孕酮口服治疗,对照组患者不接受任何额外药物干预。比较两组治疗效果。结果观察组的食欲、KPS评分、体质量增加率及无严重疲劳率均高于对照组(P<0.05);观察组患者的毒副反应发生率均显著低于对照组(P<0.05);观察组治疗后生活质量评分均高于对照组(P<0.05)。结论口服醋酸甲地孕酮在消化道肿瘤患者接受化疗过程中,有利于改善患者食欲,提升体质量,缓解患者疲劳,具有较高的临床推广价值。

Objective To study the effect of megestrol acetate in chemotherapy of patients with digestive tract tumor.Methods Seventy-four cases of digestive tract tumor patients who received chemotherapy in our hospital from March 2017 to April 2018 were selected as the study objects and divided into observation group and control group by computer random number method,with 37 cases in each group.Patients in both groups received conventional chemotherapy,the patients in the observation group were treated with oral megestrol acetate,and the patients in the control group did not receive any additional drug intervention.The treatment effects of the two groups were compared.Results Increasing rate of appetite,KPS score and body quality and no serious fatigue rate in the observation group were higher those in the control group(P<0.05);the incidences of toxic and side effects in the observation group were significantly lower than those in the control group(P<0.05).The scores of quality of life in the observation group were higher than those in the control group after treatment(P<0.05).Conclusion Oral treatment with megestrol acetate in the course of chemotherapy for patients with digestive tract tumors is beneficial to ameliorate the appetite of patients,improve the body-mass and relieve patients fatigue,which has a high clinical promotion value.