腹腔镜胆囊切除术与开腹胆囊切除术对急性结石性胆囊炎患者炎症因子水平、凝血功能及生活质量的影响

Effects of laparoscopic cholecystectomy and open cholecystectomy on inflammatory factors,coagulation function and quality of life in patients with acute calculous cholecystitis

目的比较腹腔镜胆囊切除术(LC)与开腹胆囊切除术(OC)对急性结石性胆囊炎(ACC)患者炎症因子水平、凝血功能及生活质量的影响。方法将我院收治的144例ACC患者按治疗方案的不同分为LC组(72例,腹腔镜胆囊切除术)与OC组(72例,开腹胆囊切除术)。比较两组炎症因子水平、凝血功能及生活质量。结果术前,两组IL-6、CRP、TNF-α、PT、D-D、FIB水平无显著差异(P>0.05);术后24h,LC组IL-6、CRP、TNF-α低于OC组,D-D、FIB水平高于OC组(P<0.05)。随访3个月后,LC组生活质量各维度评分及总分均高于OC组(P<0.05)。结论LC治疗ACC对机体刺激小,能减少炎症因子,提高生活质量,但术后患者易发生血栓。

Objective To compare the effects of laparoscopic cholecystectomy(LC)and open cholecystectomy(OC)on inflammatory factors,coagulation function and quality of life in patients with acute calculous cholecystitis(ACC).Methods A total of 144 patients with ACC admitted in our hospital were divided into LC group(72 cases,laparoscopic cholecystectomy)and OC group(72 cases,open cholecystectomy)according to the different treatment schemes.The levels of inflammatory factors,coagulation function and quality of life were compared between the two groups.Results Before operation,there were no significant differences in the levels of IL-6,CRP,TNF-a,PT,D-D and FIB between the two groups(P>0.05).At 24 hours after operation,the levels of IL-6,CRP and TNF-a in the LC group were lower than those in the OC group,and the levels of D-D and FIB in the LC group were higher than those in the OC group(P<0.05).After 3 months of follow-up,the scores of quality of life in different dimensions and total score of the LC group were higher than those of the OC group(P<0.05).Conclusion LC treatment of ACC has little stimulation to the body,can reduce inflammatory factors and improve the quality of life,but patients are prone to thrombosis after operation.