普拉洛芬滴眼液联合重组牛碱性成纤维细胞生长因子滴眼液在白内障术后角膜水肿患者中的应用研究

Application of pralofen eye drops combined with recombinant bovine basic fibroblast growth factor eye drops in patients with corneal edema after cataract surgery

目的探究普拉洛芬滴眼液联合重组牛碱性成纤维细胞生长因子滴眼液(rb-bFGF)在白内障术后角膜水肿患者中的治疗效果。方法选取我院2017年2月-2018年10月白内障术后角膜水肿患者92例(92只眼),根据治疗方案不同分为观察组(n=46)和对照组(n=46)。术后对照组采用普拉洛芬滴眼液治疗,上述基础上观察组联合rb-bFGF治疗,比较2组临床疗效、术后恢复情况(切口完全修复时间、角膜水肿消失时间、上皮完全修复时间)及药物不良反应。结果观察组总有效率97.83%(45/46)较对照组82.61%(38/46)高(P<0.05),观察组切口完全修复、角膜水肿消失及上皮完全修复时间短于对照组(P<0.05),观察组药物不良反应13.04%(6/46)与对照组15.22%(7/46)相比,无显著差异(P>0.05)。结论普拉洛芬滴眼液联合rb-bFGF在白内障术后角膜水肿患者治疗中,疗效确切,可加速术后康复进程,且不良反应少。

Objective To explore the therapeutic effect of pralofen eye drops combined with recombinant bovine basic fibroblast growth factor eye drops(rb-bFGF)in patients with corneal edema after cataract surgery.Methods From February 2017 to October2018,92 patients(92 eyes)with corneal edema after cataract surgery in our hospital were divided into observation group(n=46)and control group(n=46)according to different treatment schemes.The control group was treated with pranoprofen eye drops.On the basis of the above,the observation group was treated with rb-bFGF.The clinical efficacy,postoperative recovery(complete repair time of incision,disappearance time of corneal edema,complete repair time of epithelium)and adverse drug reactions were compared between the two groups.Results The total effective rate of the observation group was 97.83%(45/46)higher than 82.61%(38/46)of the control group(P<0.05).The time of complete,wound repair,corneal edema disappearance and epithelial repair in the observation group was shorter than that in the control group(P<0.05).The adverse drug reactions in the observation group were 13.04%(6/46)and 15.22%(7/46)of the control group,there was no significant difference(P>0.05).Conclusion Praprofen eye drops combined with rb-bFGF is effective in the treatment of corneal edema after cataract surgery,which can accelerate the recovery process and have fewer adverse reactions.