腮腺多形性腺瘤患者围手术期应用抗菌药物的研究

Application of antimicrobial agents in patients with pleomorphic adenoma of parotid gland during perioperative period

目的探讨腮腺多形性腺瘤患者围手术期应用抗菌药物的必要性。方法回顾性分析某院2015年1月-2017年1月头颈外科术后病理诊断为腮腺多形性腺瘤患者发生手术切口感染的情况,根据其是否在围手术期使用抗菌药物分为试验组和对照组。比较两组患者手术切口感染率。结果共纳入患者92例,其中试验组45例,对照组47例。两组患者手术后1周内最高体温、引流量及拔管时间比较,差异均无统计学意义(均P>0.05)。试验组患者手术切口感染率为11.11%(5/45),对照组患者手术切口感染率为14.89%(7/47);两组患者切口感染率比较,差异无统计学意义(χ~2=0.76,P=0.41)。结论腮腺多形性腺瘤患者围手术期使用抗菌药物并不能进一步降低其手术后切口感染率。

Objective To explore the necessity of antimicrobial use in patients with pleomorphic adenoma of parotid gland during perioperative period. Methods A retrospective analysis was made on the occurrence of surgical site infection(SSI) in patients with pleomorphic adenoma of parotid gland after head and neck surgery from January 2015 to January 2017, patients were divided into trial group and control group according to whether they used antimicrobial agents during perioperative period. Incidence of SSI was compared between two groups. Results A total of 92 patients were enrolled, including 45 in trial group and 47 in control group. There were no significant difference in maximum body temperature, drainage volume, and extubation time between two groups of patients within 1 week after operation (all P >0.05). Incision of SSI in trial group and control group were 11.11%(5/45) and 14.89%(7/47) respectively, there was no significant difference in SSI incidence between two groups(χ 2=0.76,P =0.41). Conclusion Perioperative use of antimicrobial agents in patients with pleomorphic adenoma of parotid gland can not further reduce the incidence of SSI after operation.