纳络酮联合醒脑静注射液治疗急性酒精中毒意识障碍的效果及不良反应率分析

Effect of Naloxone Combined with Xingnaojing Injection on Acute Alcoholism Conscious Disturbance and Analysis of Adverse Reaction Rate

目的研究纳络酮联合醒脑静注射液治疗急性酒精中毒意识障碍的效果及不良反应率。方法根据随机数字表法将方便选取的2016年6月-2018年5月期间该院接收的急性酒精中毒意识障碍患者60例分为对照组和观察组,30例/组,两组均接受常规治疗,对照组使用纳络酮,观察组在其基础上采用醒脑静注射液。将两组急性酒精中毒意识障碍患者的临床效果、催醒时间、急诊留观时间、格拉斯哥昏迷评分和神经功能缺损评分、不良反应发生情况进行比对。结果观察组急性酒精中毒意识障碍患者的临床总有效率(100.00%)高于对照组(86.67%),差异有统计学意义(χ^2=4.286,P=0.038);观察组患者的催醒时间[(2.10±0.38)h]、急诊留观时间[(6.22±1.13)h]均显著短于对照组数据[(4.83±0.71)h、(10.73±2.34)h],差异有统计学意义(t=18.568、9.506,P=0.001、0.001);治疗后的GCS评分(8.07±1.13)分和NIHSS评分(6.17±1.45)分明显低于对照组[(15.37±2.16)分、(11.43±4.48)分],差异有统计学意义(t=16.402、6.118,P=0.001、0.001);对照组及观察组的不良反应发生率(13.33%、10.00%)进行比较差异无统计学意义(χ^2=0.162,P=0.687)。结论对急性酒精中毒意识障碍患者采用纳络酮联合醒脑静注射液治疗安全有效,临床推广应用价值高。

Objective To study the effect and adverse reaction rate of naloxone combined with Xingnaojing injection in the treatment of acute alcoholism disturbance. Methods According to the random number table method, 60 patients with acute alcoholism conscious disturbance received by our hospital from June 2016 to May 2018 were convenient divided into control group and observation group, 30 cases/group, both groups received routine treatment. The control group was treated with naloxone, and the observation group was treated with Xingnaojing injection. The clinical effects, wake-up time, emergency observation time, Glasgow coma score and neurological deficit score, and adverse reactions were compared between two groups of patients with acute alcoholism disturbance. Results The total clinical effective rate (100.00%) of the patients with acute alcoholism disturbance in the observation group was higher than that of the control group (86.67%). The difference was statistically significant (χ^2=4.286, P=0.038). The wake-up time of the observation group patients [(2.10±0.38)h], emergency observation time [(6.22±1.13)h] was significantly shorter than the control data [(4.83±0.71)h,(10.73±2.34)h], the difference was statistically significant ( t=18.568, 9.506, P=0.001, 0.001);the GCS score (8.07±1.13)points and NIHSS score (6.17±1.45)points after treatment were significantly lower than the control group [(15.37±2.16)points,(11.43±4.48)points]. The difference was statistically significant (t=16.402, 6.118, P=0.001, 0.001);the incidence of adverse reactions in the control group and the observation group (13.33%, 10.00%) was not statistically significant (χ^2=0.162, P=0.687). Conclusion The treatment of acute alcoholism dysfunction patients with naloxone combined with Xingnaojing injection is safe and effective, and has high clinical application value.